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Tchem
RAB7A
Ras-related protein Rab-7a

Protein Summary
Description
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the l ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265062
  • ENSP00000265062
  • ENSG00000075785

Symbol
  • RAB7
  • RAB7
  • PRO2706
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
transcription factor perturbation
0.98
biological process
0.96
kinase perturbation
0.96
disease perturbation
0.93


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.15   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 329   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 500.15   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 329   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 22
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (22)
CHEMBL1328505,CHEMBL4079309
Rendered image for CHEMBL1328505,CHEMBL4079309
Guanosine triphosphate
Rendered image for Guanosine triphosphate
CHEMBL4097338
Rendered image for CHEMBL4097338
CHEMBL384759
Rendered image for CHEMBL384759
CHEMBL4098837
Rendered image for CHEMBL4098837
CHEMBL4080794
Rendered image for CHEMBL4080794
CHEMBL4091094
Rendered image for CHEMBL4091094
CHEMBL4068483
Rendered image for CHEMBL4068483
CHEMBL4069652
Rendered image for CHEMBL4069652
CHEMBL4089622
Rendered image for CHEMBL4089622
Protein-Protein Interactions (470)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999035973
p_ni:  0.000964027
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
RILP
Tbio
Novelty:  0.08339816
Score:  0.998
Data Source:  Reactome,STRINGDB
MON1A
Tbio
Novelty:  0.04537045
Score:  0.995
Data Source:  Reactome,STRINGDB
MON1B
Tbio
Novelty:  0.13486379
Score:  0.995
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.992
Data Source:  STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.991
Data Source:  Reactome,STRINGDB
CCZ1
Tbio
Novelty:  0.09830652
Score:  0.99
Data Source:  Reactome,STRINGDB
CCZ1B
Tdark
Novelty:  0.09724624
Score:  0.99
Data Source:  STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
Score:  0.99
Data Source:  STRINGDB
RAB5C
Tbio
Family:  Enzyme
Novelty:  0.02952779
Score:  0.989
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (111)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MHC class II antigen presentation
Reactome
Membrane Trafficking
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Innate Immune System
MHC class II antigen presentation
Membrane Trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
7
6
10
99
eosinophil percentage of leukocytes
2
5
5
98.3
monocyte count
4
4
5
98.3
basophil count
6
4
8
97.9
neutrophil count
2
4
4
97
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
10
99
eosinophil percentage of leukocytes
5
98.3
monocyte count
5
98.3
basophil count
8
97.9
neutrophil count
4
97
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB7A, member RAS oncogene family
VGNC:9694
470919
Mouse
MGI:105068
19349
Rat
RGD:61908
29448
Dog
RAB7A, member RAS oncogene family
VGNC:45293
404007
Horse
RAB7A, member RAS oncogene family
VGNC:22126
100050015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB7A, member RAS oncogene family
Mouse
Rat
Dog
RAB7A, member RAS oncogene family
Horse
RAB7A, member RAS oncogene family
Publication Statistics
PubMed Score 500.15
PubMed score by year
PubTator Score 45.48
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title