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Tbio
RAB4A
Ras-related protein Rab-4A

Protein Summary
Description
Protein transport. Probably involved in vesicular traffic (By similarity). This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366690
  • ENSP00000355651
  • ENSG00000168118

Symbol
  • RAB4
  • RAB4
  • HRES1
  • HRES-1
  • HRES-1/RAB4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
molecular function
0.96
kinase perturbation
0.95
virus perturbation
0.95
transcription factor binding site profile
0.87


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.63   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 309   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 212.63   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 309   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999999801
p_ni:  1.99e-7
Score:  0.662
Data Source:  BioPlex,STRINGDB
LAMP1
Tbio
Novelty:  0.00067563
p_int:  0.998796671
p_ni:  0.001061256
p_wrong:  0.000142073
Score:  0.708
Data Source:  BioPlex,STRINGDB
SCCPDH
Tbio
Family:  Enzyme
Novelty:  0.06603568
p_int:  0.997943488
p_ni:  0.002056505
p_wrong:  7e-9
Score:  0.2
Data Source:  BioPlex,STRINGDB
LRIG1
Tbio
Novelty:  0.01078663
p_int:  0.997087111
p_ni:  0.002912887
p_wrong:  2e-9
Score:  0.337
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.996117789
p_ni:  0.003882211
p_wrong:  1e-9
Score:  0.945
Data Source:  BioPlex,STRINGDB
ECSCR
Tbio
Novelty:  0.11603718
p_int:  0.991070138
p_ni:  0.008923704
p_wrong:  0.000006158
Data Source:  BioPlex
CACNG1
Tbio
Family:  IC
Novelty:  0.11899252
p_int:  0.990117486
p_ni:  0.001801737
p_wrong:  0.008080777
Data Source:  BioPlex
GRPR
Tchem
Family:  GPCR
Novelty:  0.00282511
p_int:  0.988863196
p_ni:  0.009762103
p_wrong:  0.001374701
Score:  0.2
Data Source:  BioPlex,STRINGDB
EREG
Tbio
Novelty:  0.00371897
p_int:  0.986377374
p_ni:  0.011467036
p_wrong:  0.00215559
Score:  0.461
Data Source:  BioPlex,STRINGDB
CD226
Tbio
Novelty:  0.00374102
p_int:  0.984773325
p_ni:  0.005623184
p_wrong:  0.009603491
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
MET receptor recycling (R-HSA-8875656)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
MET receptor recycling
Reactome
Membrane Trafficking
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
MET receptor recycling
Membrane Trafficking
Metabolism
Metabolism of lipids
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB4A, member RAS oncogene family
VGNC:14174
742697
Macaque
RAB4A, member RAS oncogene family
694288
Mouse
MGI:105069
19341
Rat
RGD:3529
25532
Dog
RAB4A, member RAS oncogene family
VGNC:45290
479210
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB4A, member RAS oncogene family
Macaque
RAB4A, member RAS oncogene family
Mouse
Rat
Dog
RAB4A, member RAS oncogene family
Publication Statistics
PubMed Score 212.63
PubMed score by year
PubTator Score 102.92
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title