Tbio RAB3IL1 Guanine nucleotide exchange factor for Rab-3A

Protein Summary

Description

Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q8TBN0
• Q86V32
• Q9P1Q8

Gene Name

• RAB3IL1

Ensembl ID

• ENST00000301773
• ENSP00000301773
• ENSG00000167994
• ENST00000394836
• ENSP00000378313

Symbol

• GRAB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.81
small molecule perturbation	0.73
cell line	0.66
histone modification site profile	0.65
disease perturbation	0.62

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Guanine Nucleotide Exchange Factor For Rab-3a

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Guanine Nucleotide Exchange Factor For Rab-3a

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (71)

Explore Interacting Targets

1 – 10 of 71

• See Interactions on String-DB

TMEM102

Tbio

Novelty:  0.1239857

p_int:  0.999999995

p_ni:  3e-9

p_wrong:  2e-9

Score:  0.693

Data Source:  BioPlex,STRINGDB

RAB3IP

Tbio

Novelty:  0.04046982

p_int:  0.99999949

p_ni:  1e-9

p_wrong:  5.09e-7

Score:  0.726

Data Source:  BioPlex,STRINGDB

PPFIA3

Tbio

Novelty:  0.03837299

p_int:  0.999999466

p_ni:  5.2e-8

p_wrong:  4.82e-7

Score:  0.267

Data Source:  BioPlex,STRINGDB

OPTN

Tbio

Novelty:  0.00080427

p_int:  0.999985852

p_ni:  0.000014144

p_wrong:  4e-9

Score:  0.255

Data Source:  BioPlex,STRINGDB

ATG4C

Tbio

Family:  Enzyme

Novelty:  0.04175533

p_int:  0.999958558

p_ni:  0.000038167

p_wrong:  0.000003275

Score:  0.237

Data Source:  BioPlex,STRINGDB

GDF5

Tbio

Novelty:  0.00218118

p_int:  0.999908088

p_ni:  0.000091912

Score:  0.638

Data Source:  BioPlex,STRINGDB

SYCE1

Tbio

Novelty:  0.05038876

p_int:  0.999008616

p_ni:  0.000484518

p_wrong:  0.000506866

Data Source:  BioPlex

CCDC102A

Tdark

Novelty:  1.89784272

p_int:  0.996795943

p_ni:  0.003203727

p_wrong:  3.3e-7

Score:  0.205

Data Source:  BioPlex,STRINGDB

SUGP2

Tdark

Novelty:  0.49154081

p_int:  0.996472655

p_ni:  0.003527345

Score:  0.228

Data Source:  BioPlex,STRINGDB

AMOT

Tbio

Novelty:  0.01269856

p_int:  0.979502277

p_ni:  0.020497723

Score:  0.188

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (6)

Reactome (4)

WikiPathways (2)

Membrane Trafficking (R-HSA-199991)

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1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Membrane Trafficking	612 targets	R-HSA-199991
Reactome	RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Reactome	Rab regulation of trafficking	123 targets	R-HSA-9007101
Reactome	Vesicle-mediated transport	725 targets	R-HSA-5653656

Name	Explore in Pharos	Explore in Source
Membrane Trafficking	612 targets	R-HSA-199991
RAB GEFs exchange GTP for GDP on RABs	90 targets	R-HSA-8876198
Rab regulation of trafficking	123 targets	R-HSA-9007101
Vesicle-mediated transport	725 targets	R-HSA-5653656

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (3)

Functions (1)

Components (1)

Processes (1)

Find Similar Targets

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
Rab guanyl-nucleotide exchange factor activity	Inferred from Direct Assay (IDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (104)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 104

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	5	12	30		99.9
high density lipoprotein cholesterol measurement	EFO_0004612	13	19	34	1.9	99.8
docosapentaenoic acid measurement	EFO_0006809	2	10	11		99.8
serum metabolite measurement	EFO_0005653	7	36	212		99.8
triglyceride measurement	EFO_0004530	16	18	43	3.8	99.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 104

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
blood metabolite measurement	EFO_0005664	30		99.9
high density lipoprotein cholesterol measurement	EFO_0004612	34	1.9	99.8
docosapentaenoic acid measurement	EFO_0006809	11		99.8
serum metabolite measurement	EFO_0005653	212		99.8
triglyceride measurement	EFO_0004530	43	3.8	99.7

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Coiled coil
Complete proteome
Guanine-nucleotide releasing factor
Phosphoprotein
Polymorphism
Protein transport
Reference proteome
Transport

GWAS Trait Find Similar Targets

No Header	No Header
adult onset asthma
albumin:globulin ratio measurement
alkaline phosphatase measurement
Alopecia
alpha-linolenic acid measurement
aortic stenosis
apolipoprotein A 1 measurement
apolipoprotein B measurement
arachidonic acid measurement
aspartate aminotransferase measurement

IDG Resources

No IDG generated resources found

Orthologs (10)

1 – 5 of 10

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RAB3A interacting protein like 1	VGNC:10190	466629
Macaque	RAB3A interacting protein like 1		719016
Mouse	RAB3A interacting protein (rabin3)-like 1	MGI:1922010	74760
Rat	RAB3A interacting protein-like 1	RGD:619764	171452
Dog	RAB3A interacting protein like 1	VGNC:45288	612267

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RAB3A interacting protein like 1
Macaque	RAB3A interacting protein like 1
Mouse	RAB3A interacting protein (rabin3)-like 1
Rat	RAB3A interacting protein-like 1
Dog	RAB3A interacting protein like 1

Publication Statistics

PubMed Score 61.87

PubMed score by year

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PubTator Score 14.68

PubTator score by year

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Related Publications

Text Mined References (13)

GeneRif Annotations (1)

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10

0 of 0

PMID	Year	Title