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Tbio
RAB3IL1
Guanine nucleotide exchange factor for Rab-3A

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) which may activate RAB3A, a GTPase that regulates synaptic vesicle exocytosis. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May also activate RAB8A and RAB8B. This gene encodes a guanine nucleotide exchange factor for the ras-related protein Rab3A. The encoded protein binds Rab3a and the inositol hexakisphosphate kinase InsP6K1. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301773
  • ENSP00000301773
  • ENSG00000167994
  • ENST00000394836
  • ENSP00000378313

Symbol
  • GRAB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.81
small molecule perturbation
0.73
cell line
0.66
histone modification site profile
0.65
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 174   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.87   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
TMEM102
Tbio
Novelty:  0.1239857
p_int:  0.999999995
p_ni:  3e-9
p_wrong:  2e-9
Score:  0.693
Data Source:  BioPlex,STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
p_int:  0.99999949
p_ni:  1e-9
p_wrong:  5.09e-7
Score:  0.726
Data Source:  BioPlex,STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
p_int:  0.999999466
p_ni:  5.2e-8
p_wrong:  4.82e-7
Score:  0.267
Data Source:  BioPlex,STRINGDB
OPTN
Tbio
Novelty:  0.00080427
p_int:  0.999985852
p_ni:  0.000014144
p_wrong:  4e-9
Score:  0.255
Data Source:  BioPlex,STRINGDB
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.999958558
p_ni:  0.000038167
p_wrong:  0.000003275
Score:  0.237
Data Source:  BioPlex,STRINGDB
GDF5
Tbio
Novelty:  0.00218118
p_int:  0.999908088
p_ni:  0.000091912
Score:  0.638
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999008616
p_ni:  0.000484518
p_wrong:  0.000506866
Data Source:  BioPlex
CCDC102A
Tdark
Novelty:  1.89784272
p_int:  0.996795943
p_ni:  0.003203727
p_wrong:  3.3e-7
Score:  0.205
Data Source:  BioPlex,STRINGDB
SUGP2
Tdark
Novelty:  0.49154081
p_int:  0.996472655
p_ni:  0.003527345
Score:  0.228
Data Source:  BioPlex,STRINGDB
AMOT
Tbio
Novelty:  0.01269856
p_int:  0.979502277
p_ni:  0.020497723
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (104)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
5
12
30
99.9
high density lipoprotein cholesterol measurement
13
19
34
1.9
99.8
docosapentaenoic acid measurement
2
10
11
99.8
serum metabolite measurement
7
36
212
99.8
triglyceride measurement
16
18
43
3.8
99.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
30
99.9
high density lipoprotein cholesterol measurement
34
1.9
99.8
docosapentaenoic acid measurement
11
99.8
serum metabolite measurement
212
99.8
triglyceride measurement
43
3.8
99.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3A interacting protein like 1
VGNC:10190
466629
Macaque
RAB3A interacting protein like 1
719016
Mouse
MGI:1922010
74760
Rat
RGD:619764
171452
Dog
RAB3A interacting protein like 1
VGNC:45288
612267
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3A interacting protein like 1
Macaque
RAB3A interacting protein like 1
Mouse
Rat
Dog
RAB3A interacting protein like 1
Publication Statistics
PubMed Score 61.87
PubMed score by year
PubTator Score 14.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title