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Tbio
RAB3GAP1
Rab3 GTPase-activating protein catalytic subunit

Protein Summary
Description
Probable catalytic subunit of a GTPase activating protein that has specificity for Rab3 subfamily (RAB3A, RAB3B, RAB3C and RAB3D). Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. Specifically converts active Rab3-GTP to the inactive form Rab3-GDP. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. This gene encodes the catalytic subunit of a Rab GTPase activating protein. The encoded protein forms a heterodimer with a non-catalytic subunit to specifically regulate the activity of members of the Rab3 subfamily of small G proteins. This protein mediates the hydrolysis of GTP bound Rab3 to the GDP bound form. Mutations in this gene are associated with Warburg micro syndrome. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264158
  • ENSP00000264158
  • ENSG00000115839
  • ENST00000442034
  • ENSP00000411418
  • ENST00000539493
  • ENSP00000444306

Symbol
  • KIAA0066
  • RAB3GAP
  • P130
  • WARBM1
  • RAB3GAP
  • RAB3GAP130
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
interacting protein
0.7
biological process
0.67
cell type or tissue
0.65
molecular function
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.96   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 146   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.96   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 146   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (111)
BRAF
Tclin
Family:  Kinase
Novelty:  0.00253795
p_int:  0.999999923
p_ni:  7.7e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
SIRT2
Tchem
Family:  Epigenetic
Novelty:  0.00093962
p_int:  0.999999845
p_ni:  1.54e-7
Score:  0.202
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.999993497
p_ni:  0.000006503
Score:  0.511
Data Source:  BioPlex,STRINGDB
VAPA
Tbio
Novelty:  0.00169209
p_int:  0.999955453
p_ni:  0.000044547
Score:  0.433
Data Source:  BioPlex,STRINGDB
GMFB
Tbio
Novelty:  0.01531815
p_int:  0.999833743
p_ni:  0.000166256
p_wrong:  1e-9
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.996556637
p_ni:  0.003443362
Data Source:  BioPlex
BTN2A1
Tbio
Novelty:  0.02259329
p_int:  0.995622611
p_ni:  0.004377389
Data Source:  BioPlex
C6orf141
Tdark
Novelty:  1.46022784
p_int:  0.98922913
p_ni:  0.01077087
Data Source:  BioPlex
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
p_int:  0.978256955
p_ni:  0.021743012
p_wrong:  3.3e-8
Data Source:  BioPlex
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.952913122
p_ni:  0.047073566
p_wrong:  0.000013312
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
COPI-independent Golgi-to-ER retrograde traffic (R-HSA-6811436)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-independent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Name
Explore in Pharos
Explore in Source
COPI-independent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
24
5
19
8.8
98.1
blood metabolite measurement
1
1
1
87.3
1
1
0
1.6
76.9
total cholesterol measurement
1
1
1
66.9
1
1
0
1.6
61.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gut microbiome measurement
19
8.8
98.1
blood metabolite measurement
1
87.3
0
1.6
76.9
total cholesterol measurement
1
66.9
0
1.6
61.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB3 GTPase activating protein catalytic subunit 1
VGNC:2796
470548
Macaque
RAB3 GTPase activating protein catalytic subunit 1
708191
Mouse
MGI:2445001
226407
Rat
RGD:1306487
304759
Dog
RAB3 GTPase activating protein catalytic subunit 1
VGNC:45286
476127
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB3 GTPase activating protein catalytic subunit 1
Macaque
RAB3 GTPase activating protein catalytic subunit 1
Mouse
Rat
Dog
RAB3 GTPase activating protein catalytic subunit 1
Publication Statistics
PubMed Score 42.96
PubMed score by year
PubTator Score 33.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title