Tbio RAB3A Ras-related protein Rab-3A

Protein Summary

Description

Involved in exocytosis by regulating a late step in synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal.

Uniprot Accession IDs

• P20336
• A8K0J4
• Q9NYE1

Gene Name

• RAB3A

Ensembl ID

• ENST00000222256
• ENSP00000222256
• ENSG00000105649

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.99
cellular component	0.91
biological process	0.9
histone modification site profile	0.89
small molecule perturbation	0.77

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.36   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 322   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.36   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 322   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (230)

Explore Interacting Targets

1 – 10 of 230

• See Interactions on String-DB

RAB3B

Tbio

Family:  Enzyme

Novelty:  0.02731183

p_int:  0.999999992

p_ni:  2e-9

p_wrong:  6e-9

Score:  0.975

Data Source:  BioPlex,STRINGDB

SYTL4

Tbio

Novelty:  0.03934385

p_int:  0.999999571

p_ni:  4.19e-7

p_wrong:  1.1e-8

Score:  0.764

Data Source:  BioPlex,STRINGDB

CHM

Tbio

Family:  Enzyme

Novelty:  0.00226278

p_int:  0.999965688

p_ni:  0.000034312

Score:  0.97

Data Source:  BioPlex,Reactome,STRINGDB

CHML

Tbio

Family:  Enzyme

Novelty:  0.00509709

p_int:  0.999453493

p_ni:  0.000546506

p_wrong:  1e-9

Score:  0.954

Data Source:  BioPlex,Reactome,STRINGDB

NUFIP1

Tbio

Novelty:  0.11726869

p_int:  0.999365211

p_ni:  0.000634768

p_wrong:  2.1e-8

Data Source:  BioPlex

RABIF

Tbio

Novelty:  0.22512579

p_int:  0.998295603

p_ni:  0.001704175

p_wrong:  2.21e-7

Score:  0.793

Data Source:  BioPlex,STRINGDB

RANGRF

Tbio

Family:  Enzyme

Novelty:  0.02750539

p_int:  0.993727833

p_ni:  0.00130058

p_wrong:  0.004971587

Data Source:  BioPlex

RAB33B

Tbio

Family:  Enzyme

Novelty:  0.06381712

p_int:  0.987041532

p_ni:  0.012955568

p_wrong:  0.0000029

Score:  0.928

Data Source:  BioPlex,STRINGDB

GDI1

Tbio

Novelty:  0.01710945

p_int:  0.985538267

p_ni:  0.014461733

Score:  0.967

Data Source:  BioPlex,Reactome,STRINGDB

SLC15A1

Tchem

Family:  Transporter

Novelty:  0.00149723

p_int:  0.980576687

p_ni:  0.008786226

p_wrong:  0.010637087

Score:  0.154

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (24)

Reactome (19)

KEGG (2)

PathwayCommons (1)

WikiPathways (2)

Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

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Find Similar Targets

Items per page:

5

1 – 5 of 19

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Reactome	Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
Reactome	GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Reactome	Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Acetylcholine Neurotransmitter Release Cycle	17 targets	R-HSA-264642
Dopamine Neurotransmitter Release Cycle	23 targets	R-HSA-212676
GABA synthesis, release, reuptake and degradation	19 targets	R-HSA-888590
Glutamate Neurotransmitter Release Cycle	24 targets	R-HSA-210500
Immune System	2246 targets	R-HSA-168256

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (52)

Functions (8)

Components (17)

Processes (27)

Find Similar Targets

Items per page:

10

1 – 8 of 8

GO Term	Evidence	Assigned by
GTPase activity	Inferred from Direct Assay (IDA)	UniProtKB
myosin V binding	Inferred from Physical Interaction (IPI)	UniProtKB
ATPase activator activity	Inferred from Electronic Annotation (IEA)	Ensembl
ATPase binding	Inferred from Electronic Annotation (IEA)	Ensembl
GDP-dissociation inhibitor binding	Inferred from Electronic Annotation (IEA)	Ensembl
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
GTP-dependent protein binding	Inferred from Electronic Annotation (IEA)	Ensembl
protein C-terminus binding	Inferred from Electronic Annotation (IEA)	Ensembl

Disease Associations ()

No disease associations found

GWAS Traits (42)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 5 of 42

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	13	18	32		98.2
waist-hip ratio	EFO_0004343	5	15	17		98.1
waist circumference	EFO_0004342	1	8	8		93.8
BMI-adjusted waist circumference	EFO_0007789	3	9	10		92.7
serum alanine aminotransferase measurement	EFO_0004735	2	2	1	9.8	89.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 42

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
BMI-adjusted waist-hip ratio	EFO_0007788	32		98.2
waist-hip ratio	EFO_0004343	17		98.1
waist circumference	EFO_0004342	8		93.8
BMI-adjusted waist circumference	EFO_0007789	10		92.7
serum alanine aminotransferase measurement	EFO_0004735	1	9.8	89.5

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UniProt Keyword Find Similar Targets

No Header	No Header
Cell membrane
Complete proteome
Exocytosis
GTP-binding
Lipoprotein
Membrane
Methylation
Nucleotide-binding
Phosphoprotein
Prenylation

GWAS Trait Find Similar Targets

No Header	No Header
alkaline phosphatase measurement
apolipoprotein B measurement
appendicular lean mass
autoimmune thyroid disease
basophil count
basophil percentage of leukocytes
blood protein measurement
BMI-adjusted waist circumference
BMI-adjusted waist-hip ratio
body fat percentage

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
nervous system phenotype

IDG Resources

No IDG generated resources found

Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RAB3A, member RAS oncogene family	VGNC:7569	455857
Macaque	RAB3A, member RAS oncogene family		719400
Mouse	RAB3A, member RAS oncogene family	MGI:97843	19339
Rat	RAB3A, member RAS oncogene family	RGD:3528	25531
Dog	RAB3A, member RAS oncogene family	VGNC:45282	484826

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RAB3A, member RAS oncogene family
Macaque	RAB3A, member RAS oncogene family
Mouse	RAB3A, member RAS oncogene family
Rat	RAB3A, member RAS oncogene family
Dog	RAB3A, member RAS oncogene family

Publication Statistics

PubMed Score 232.36

PubMed score by year

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PubTator Score 135.99

PubTator score by year

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Related Publications

Text Mined References (63)

GeneRif Annotations (17)

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10

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PMID	Year	Title