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Tbio
RAB38
Ras-related protein Rab-38

Protein Summary
Description
May be involved in melanosomal transport and docking. Involved in the proper sorting of TYRP1. Involved in peripheral melanosomal distribution of TYRP1 in melanocytes; the function, which probably is implicating vesicle-trafficking, includes cooperation with ANKRD27 and VAMP7 (By similarity). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB32, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000243662
  • ENSP00000243662
  • ENSG00000123892

Symbol
  • rrGTPbp
  • NY-MEL-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
tissue sample
0.77
PubMedID
0.76
cellular component
0.73
histone modification site profile
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.95   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.95   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (113)
RAB32
Tbio
Family:  Enzyme
Novelty:  0.02514559
p_int:  0.999999458
p_wrong:  5.42e-7
Score:  0.94
Data Source:  BioPlex,STRINGDB
HPS4
Tbio
Novelty:  0.03363833
Score:  0.969
Data Source:  Reactome,STRINGDB
HPS1
Tbio
Novelty:  0.44609665
Score:  0.947
Data Source:  Reactome,STRINGDB
RAB42
Tdark
Family:  Enzyme
Novelty:  0.63833605
Score:  0.945
Data Source:  STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
Score:  0.933
Data Source:  Reactome,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.929
Data Source:  Reactome,STRINGDB
RAB21
Tbio
Family:  Enzyme
Novelty:  0.03221825
Score:  0.928
Data Source:  STRINGDB
P0DI83
Tbio
Novelty:  0.03645677
Score:  0.928
Data Source:  STRINGDB
RAB20
Tbio
Family:  Enzyme
Novelty:  0.06768944
Score:  0.928
Data Source:  STRINGDB
Q9BZG1
Tbio
Family:  Enzyme
Novelty:  0.03645677
Score:  0.928
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
38.2
gut microbiome measurement
1
1
0
6
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
38.2
gut microbiome measurement
0
6
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB38, member RAS oncogene family
VGNC:7662
451468
Macaque
RAB38, member RAS oncogene family
705189
Mouse
MGI:1919683
72433
Rat
RGD:628752
252916
Dog
RAB38, member RAS oncogene family
VGNC:45280
608181
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB38, member RAS oncogene family
Macaque
RAB38, member RAS oncogene family
Mouse
Rat
Dog
RAB38, member RAS oncogene family
Publication Statistics
PubMed Score 42.95
PubMed score by year
PubTator Score 23.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title