Tbio RAB2B Ras-related protein Rab-2B

Protein Summary

Description

Required for protein transport from the endoplasmic reticulum to the Golgi complex. Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

Uniprot Accession IDs

• Q8WUD1
• B2RD03
• D3DS24
• Q6NZ33

Gene Name

• RAB2B

Ensembl ID

• ENST00000397762
• ENSP00000380869
• ENSG00000129472

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
histone modification site profile	0.91
kinase perturbation	0.91
molecular function	0.91
virus perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 193   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.42   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (120)

Explore Interacting Targets

1 – 10 of 120

• See Interactions on String-DB

FAM71F2

Tdark

Novelty:  0.56916996

p_int:  0.999999889

p_ni:  1.11e-7

Score:  0.903

Data Source:  BioPlex,STRINGDB

RAB2A

Tchem

Family:  Enzyme

Novelty:  0.00629151

p_int:  0.999999485

p_ni:  5.14e-7

p_wrong:  1e-9

Score:  0.975

Data Source:  BioPlex,STRINGDB

CHM

Tbio

Family:  Enzyme

Novelty:  0.00226278

p_int:  0.999998083

p_ni:  0.000001917

Score:  0.922

Data Source:  BioPlex,STRINGDB

CHML

Tbio

Family:  Enzyme

Novelty:  0.00509709

p_int:  0.999997451

p_ni:  0.000002549

Score:  0.927

Data Source:  BioPlex,STRINGDB

PGGT1B

Tchem

Family:  Enzyme

Novelty:  0.08041103

p_int:  0.9999958

p_ni:  0.000004197

p_wrong:  2e-9

Score:  0.23

Data Source:  BioPlex,STRINGDB

GDI1

Tbio

Novelty:  0.01710945

p_int:  0.999989479

p_ni:  0.000010521

Score:  0.827

Data Source:  BioPlex,STRINGDB

RAB5B

Tbio

Family:  Enzyme

Novelty:  0.02653775

p_int:  0.999938851

p_ni:  0.000060279

p_wrong:  8.71e-7

Score:  0.97

Data Source:  BioPlex,STRINGDB

RAB14

Tbio

Family:  Enzyme

Novelty:  0.01876172

p_int:  0.999626951

p_ni:  0.000373049

Score:  0.985

Data Source:  BioPlex,STRINGDB

BTAF1

Tbio

Novelty:  0.01586704

p_int:  0.999621468

p_ni:  0.000378532

Data Source:  BioPlex

PRUNE1

Tchem

Novelty:  0.02136836

p_int:  0.999535437

p_ni:  0.000464528

p_wrong:  3.5e-8

Score:  0.212

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (3)

Reactome (3)

Metabolism of proteins (R-HSA-392499)

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5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499
Reactome	Post-translational protein modification	1450 targets	R-HSA-597592
Reactome	RAB geranylgeranylation	66 targets	R-HSA-8873719

Name	Explore in Pharos	Explore in Source
Metabolism of proteins	2050 targets	R-HSA-392499
Post-translational protein modification	1450 targets	R-HSA-597592
RAB geranylgeranylation	66 targets	R-HSA-8873719

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (11)

Functions (2)

Components (5)

Processes (4)

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10

1 – 2 of 2

GO Term	Evidence	Assigned by
GTPase activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
GTP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1	1	1		77.9
diet measurement	EFO_0008111	1	1	1		71.2
self reported educational attainment	EFO_0004784	1	1	1		59
BMI-adjusted hip circumference	EFO_0008039	1	1	1		47.7
smoking status measurement	EFO_0006527	1	1	1		15.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 5

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body height	EFO_0004339	1		77.9
diet measurement	EFO_0008111	1		71.2
self reported educational attainment	EFO_0004784	1		59
BMI-adjusted hip circumference	EFO_0008039	1		47.7
smoking status measurement	EFO_0006527	1		15.8

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Endoplasmic reticulum
ER-Golgi transport
Golgi apparatus
GTP-binding
Lipoprotein
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
diet measurement
self reported educational attainment
smoking status measurement

IDG Resources

No IDG generated resources found

Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	RAB2B, member RAS oncogene family		452763
Macaque	RAB2B, member RAS oncogene family		708273
Mouse	RAB2B, member RAS oncogene family	MGI:1923588	76338
Rat	RAB2B, member RAS oncogene family	RGD:1309117	305853
Dog	RAB2B, member RAS oncogene family	VGNC:45272	475402

Species	Name	OMA	EggNOG	Inparanoid
Chimp	RAB2B, member RAS oncogene family
Macaque	RAB2B, member RAS oncogene family
Mouse	RAB2B, member RAS oncogene family
Rat	RAB2B, member RAS oncogene family
Dog	RAB2B, member RAS oncogene family

Publication Statistics

PubMed Score 5.42

PubMed score by year

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PubTator Score 3.59

PubTator score by year

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Related Publications

Text Mined References (12)

GeneRif Annotations (2)

Items per page:

10

0 of 0

PMID	Year	Title