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Tbio
RAB26
Ras-related protein Rab-26

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland. Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000210187
  • ENSP00000210187
  • ENSG00000167964
  • ENST00000541451
  • ENSP00000441580

Symbol
  • V46133
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
cellular component
0.71
transcription factor
0.66
transcription factor perturbation
0.61
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.15   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
PTAR1
Tdark
Family:  Enzyme
Novelty:  0.37120559
p_int:  0.999999527
p_ni:  4.59e-7
p_wrong:  1.4e-8
Data Source:  BioPlex
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999203296
p_ni:  0.000796371
p_wrong:  3.33e-7
Score:  0.905
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.999036862
p_ni:  0.000963135
p_wrong:  3e-9
Score:  0.904
Data Source:  BioPlex,STRINGDB
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.997948006
p_ni:  0.002051994
Score:  0.932
Data Source:  BioPlex,STRINGDB
PCYT2
Tbio
Family:  Enzyme
Novelty:  0.03267621
p_int:  0.984629248
p_ni:  0.014272579
p_wrong:  0.001098173
Data Source:  BioPlex
RABGGTB
Tbio
Family:  Enzyme
Novelty:  0.06786314
p_int:  0.962214695
p_ni:  0.037785305
Score:  0.9
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.960020902
p_ni:  0.019871308
p_wrong:  0.02010779
Data Source:  BioPlex
RAB3A
Tbio
Family:  Enzyme
Novelty:  0.0043532
Score:  0.922
Data Source:  STRINGDB
RAB32
Tbio
Family:  Enzyme
Novelty:  0.02514559
Score:  0.921
Data Source:  STRINGDB
RAB23
Tbio
Family:  Enzyme
Novelty:  0.01686155
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of proteins (R-HSA-392499)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
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Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
2
4
91
alkaline phosphatase measurement
2
2
1
6
91
serum gamma-glutamyl transferase measurement
2
2
2
90.8
BMI-adjusted waist circumference
2
4
5
81.1
body height
3
3
3
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
4
91
alkaline phosphatase measurement
1
6
91
serum gamma-glutamyl transferase measurement
2
90.8
BMI-adjusted waist circumference
5
81.1
body height
3
80.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB26, member RAS oncogene family
VGNC:9213
453829
Macaque
RAB26, member RAS oncogene family
695143
Mouse
MGI:2443284
328778
Rat
RGD:620890
171111
Dog
RAB26, member RAS oncogene family
VGNC:45266
610958
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB26, member RAS oncogene family
Macaque
RAB26, member RAS oncogene family
Mouse
Rat
Dog
RAB26, member RAS oncogene family
Publication Statistics
PubMed Score 9.15
PubMed score by year
PubTator Score 5.04
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title