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Tbio
RAB22A
Ras-related protein Rab-22A

Protein Summary
Description
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905). The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000244040
  • ENSP00000244040
  • ENSG00000124209

Symbol
  • RAB22
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
kinase perturbation
1
molecular function
0.93
histone modification site profile
0.81
cellular component
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.61   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.61   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (140)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999999998
p_ni:  1e-9
p_wrong:  1e-9
Score:  0.811
Data Source:  BioPlex,STRINGDB
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
p_int:  0.999995629
p_wrong:  0.00000437
Score:  0.983
Data Source:  BioPlex,STRINGDB
RAB7A
Tchem
Family:  Enzyme
Novelty:  0.00192702
Score:  0.955
Data Source:  STRINGDB
RABGEF1
Tbio
Novelty:  0.02830695
Score:  0.953
Data Source:  STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
Score:  0.942
Data Source:  STRINGDB
RAB7B
Tbio
Family:  Enzyme
Novelty:  0.00207354
Score:  0.933
Data Source:  STRINGDB
Q9BZG1
Tbio
Family:  Enzyme
Novelty:  0.03645677
Score:  0.931
Data Source:  STRINGDB
P0DI83
Tbio
Novelty:  0.03645677
Score:  0.931
Data Source:  STRINGDB
EEA1
Tbio
Novelty:  0.00242832
Score:  0.931
Data Source:  STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
Score:  0.931
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
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GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB22A, member RAS oncogene family
699283
Mouse
MGI:105072
19334
Rat
RGD:1311959
366265
Dog
RAB22A, member RAS oncogene family
VGNC:45262
403864
Horse
RAB22A, member RAS oncogene family
VGNC:22095
100056212
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB22A, member RAS oncogene family
Mouse
Rat
Dog
RAB22A, member RAS oncogene family
Horse
RAB22A, member RAS oncogene family
Publication Statistics
PubMed Score 53.61
PubMed score by year
PubTator Score 22.57
PubTator score by year
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Related Publications
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PMID
Year
Title