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Tbio
RAB21
Ras-related protein Rab-21

Protein Summary
Description
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148). This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and mig ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261263
  • ENSP00000261263
  • ENSG00000080371

Symbol
  • KIAA0118
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.96
molecular function
0.93
transcription factor perturbation
0.91
kinase perturbation
0.84
cellular component
0.82


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.53   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.53   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999996819
p_ni:  0.000003181
Score:  0.925
Data Source:  BioPlex,Reactome,STRINGDB
SLC22A16
Tbio
Family:  Transporter
Novelty:  0.03379851
p_int:  0.996251235
p_ni:  0.00374876
p_wrong:  5e-9
Data Source:  BioPlex
FANCE
Tbio
Novelty:  0.04484113
p_int:  0.995884564
p_ni:  0.004115394
p_wrong:  4.1e-8
Score:  0.188
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.964186341
p_ni:  0.035813659
Score:  0.933
Data Source:  BioPlex,STRINGDB
VAC14
Tbio
Novelty:  0.02677738
p_int:  0.957429052
p_ni:  0.042570947
Data Source:  BioPlex
RABGEF1
Tbio
Novelty:  0.02830695
p_int:  0.951204759
p_ni:  0.048774542
p_wrong:  0.000020699
Score:  0.95
Data Source:  BioPlex,STRINGDB
TACR3
Tchem
Family:  GPCR
Novelty:  0.00351352
p_int:  0.924280951
p_ni:  0.075719042
p_wrong:  7e-9
Data Source:  BioPlex
SLC9A8
Tbio
Family:  Transporter
Novelty:  0.03305341
p_int:  0.915045461
p_ni:  0.08494595
p_wrong:  0.000008589
Data Source:  BioPlex
VIPR2
Tchem
Family:  GPCR
Novelty:  0.00463802
p_int:  0.906607386
p_ni:  0.093270307
p_wrong:  0.000122306
Data Source:  BioPlex
TMEM159
Tdark
Novelty:  0.22237677
p_int:  0.895250393
p_ni:  0.104709866
p_wrong:  0.000039741
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
RAB geranylgeranylation
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
RAB GEFs exchange GTP for GDP on RABs
RAB geranylgeranylation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
1
4
63.7
1
1
0
1.2
55.2
apolipoprotein B measurement
2
1
2
55.2
Cleft palate
1
1
0
1.2
55.2
total cholesterol measurement
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
63.7
0
1.2
55.2
apolipoprotein B measurement
2
55.2
Cleft palate
0
1.2
55.2
total cholesterol measurement
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB21, member RAS oncogene family
VGNC:13352
467069
Mouse
MGI:894308
216344
Rat
RGD:1303150
299799
Dog
RAB21, member RAS oncogene family
VGNC:45261
100683312
Horse
RAB21, member RAS oncogene family
VGNC:22094
100056811
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB21, member RAS oncogene family
Mouse
Rat
Dog
RAB21, member RAS oncogene family
Horse
RAB21, member RAS oncogene family
Publication Statistics
PubMed Score 34.53
PubMed score by year
PubTator Score 17.87
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title