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Tbio
RAB1A
Ras-related protein Rab-1A

Protein Summary
Description
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport. This gene encodes a member of the Ras superfamily of GTPases. Members of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000398529
  • ENSP00000381540
  • ENSG00000138069
  • ENST00000409784
  • ENSP00000387286
  • ENST00000409892
  • ENSP00000386451
  • ENST00000649427
  • ENSP00000497078

Symbol
  • RAB1
  • RAB1
  • YPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
0.97
transcription factor binding site profile
0.95
disease perturbation
0.93
biological process
0.91


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 373.35   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 373.35   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (399)
RAB1B
Tbio
Family:  Enzyme
Novelty:  0.02156819
p_int:  1
Score:  0.985
Data Source:  BioPlex,STRINGDB
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.999970873
p_ni:  0.000029127
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
CHML
Tbio
Family:  Enzyme
Novelty:  0.00509709
p_int:  0.999589494
p_ni:  0.000410506
Score:  0.976
Data Source:  BioPlex,Reactome,STRINGDB
RAB8A
Tbio
Family:  Enzyme
Novelty:  0.00486694
p_int:  0.999385637
p_ni:  0.00061435
p_wrong:  1.3e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
GDI2
Tbio
Novelty:  0.02861013
p_int:  0.997803131
p_ni:  0.002196869
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
RABIF
Tbio
Novelty:  0.22512579
p_int:  0.996519745
p_ni:  0.003480255
Score:  0.699
Data Source:  BioPlex,STRINGDB
VPS13C
Tbio
Novelty:  0.05207291
p_int:  0.995977907
p_ni:  0.004022087
p_wrong:  6e-9
Score:  0.23
Data Source:  BioPlex,STRINGDB
CHM
Tbio
Family:  Enzyme
Novelty:  0.00226278
p_int:  0.994099611
p_ni:  0.005899966
p_wrong:  4.23e-7
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
EEF1A2
Tchem
Novelty:  0.001472
p_int:  0.972877338
p_ni:  0.027122662
Data Source:  BioPlex
RABGGTA
Tdark
Family:  Enzyme
Novelty:  0.19962321
p_int:  0.876731226
p_ni:  0.123268774
Score:  0.988
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (23)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
COPI-mediated anterograde transport
Reactome
COPII-mediated vesicle transport
Reactome
Cell Cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
COPI-dependent Golgi-to-ER retrograde traffic
COPI-mediated anterograde transport
COPII-mediated vesicle transport
Cell Cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (33)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1.1
94
5
3
0
1.1
90.9
triglyceride measurement
5
4
8
89.7
testosterone measurement
3
3
3
78.4
high density lipoprotein cholesterol measurement
2
2
2
76.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
94
0
1.1
90.9
triglyceride measurement
8
89.7
testosterone measurement
3
78.4
high density lipoprotein cholesterol measurement
2
76.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAB1A, member RAS oncogene family
VGNC:10442
459280
Macaque
RAB1A, member RAS oncogene family
696962
Mouse
MGI:97842
19324
Dog
RAB1A, member RAS oncogene family
VGNC:45259
403774
Horse
RAB1A, member RAS oncogene family
VGNC:22093
100051331
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAB1A, member RAS oncogene family
Macaque
RAB1A, member RAS oncogene family
Mouse
Dog
RAB1A, member RAS oncogene family
Horse
RAB1A, member RAS oncogene family
Publication Statistics
PubMed Score 373.35
PubMed score by year
PubTator Score 187.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title