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Tbio
RAB11FIP5
Rab11 family-interacting protein 5

Protein Summary
Description
Rab effector involved in protein trafficking from apical recycling endosomes to the apical plasma membrane. Involved in insulin granule exocytosis. May regulate V-ATPase intracellular transport in response to extracellular acidosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258098
  • ENSP00000258098
  • ENSG00000135631

Symbol
  • GAF1
  • KIAA0857
  • RIP11
  • GAF1
  • pp75
  • RIP11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
interacting protein
0.95
disease perturbation
0.93
ligand (protein) perturbation
0.83
cellular component
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.38   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.994
Data Source:  BioPlex,STRINGDB
RAB11B
Tbio
Family:  Enzyme
Novelty:  0.00557558
p_int:  0.999999985
p_ni:  1.5e-8
Score:  0.94
Data Source:  BioPlex,STRINGDB
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999997423
p_ni:  0.000002577
Data Source:  BioPlex
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.999976494
p_ni:  0.000023506
Data Source:  BioPlex
ARHGAP26
Tbio
Family:  Enzyme
Novelty:  0.02409941
p_int:  0.999892347
p_ni:  0.000107653
Score:  0.378
Data Source:  BioPlex,STRINGDB
NCKIPSD
Tbio
Novelty:  0.07453111
p_int:  0.999138272
p_ni:  0.000861728
Score:  0.172
Data Source:  BioPlex,STRINGDB
ISCA2
Tbio
Novelty:  0.02194373
p_int:  0.999129311
p_ni:  0.000870689
Data Source:  BioPlex
HDGFL2
Tbio
Family:  Epigenetic
Novelty:  0.11846257
p_int:  0.964985147
p_ni:  0.035012595
p_wrong:  0.000002259
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.921697758
p_ni:  0.07830224
p_wrong:  1e-9
Data Source:  BioPlex
LZTS2
Tbio
Novelty:  0.09515452
p_int:  0.878296292
p_ni:  0.121690443
p_wrong:  0.000013265
Score:  0.152
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
1
2
3
81.4
intelligence
3
6
4
6.2
66.3
self reported educational attainment
3
3
3
57.3
glomerular filtration rate
1
1
1
47.7
bone density
1
1
2
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urinary metabolite measurement
3
81.4
intelligence
4
6.2
66.3
self reported educational attainment
3
57.3
glomerular filtration rate
1
47.7
bone density
2
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB11 family interacting protein 5
713953
Mouse
MGI:1098586
52055
Dog
RAB11 family interacting protein 5
VGNC:45252
100856651
Cow
RAB11 family interacting protein 5
VGNC:54474
535992
Chicken
RAB11 family interacting protein 5
CGNC:12025
422952
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB11 family interacting protein 5
Mouse
Dog
RAB11 family interacting protein 5
Cow
RAB11 family interacting protein 5
Chicken
RAB11 family interacting protein 5
Publication Statistics
PubMed Score 40.38
PubMed score by year
PubTator Score 25.40
PubTator score by year
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Related Publications
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PMID
Year
Title