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Tbio
RAB11FIP4
Rab11 family-interacting protein 4

Protein Summary
Description
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. In case of infection by HCMV (human cytomegalovirus), may participate in egress of the virus out of nucleus; this function is independent of ARF6. The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394744
  • ENSP00000378227
  • ENSG00000131242
  • ENST00000621161
  • ENSP00000482620

Symbol
  • ARFO2
  • KIAA1821
  • FIP4-Rab11
  • RAB11-FIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.85
transcription factor perturbation
0.84
cell type or tissue
0.82
kinase perturbation
0.81
cellular component
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.61   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (62)
RAB11FIP3
Tbio
Novelty:  0.07915085
p_int:  1
Score:  0.916
Data Source:  BioPlex,STRINGDB
TNIP2
Tbio
Novelty:  0.03640252
p_int:  0.999999782
p_ni:  2.17e-7
p_wrong:  1e-9
Score:  0.187
Data Source:  BioPlex,STRINGDB
SPECC1
Tbio
Novelty:  0.00830299
p_int:  0.999999158
p_ni:  3.75e-7
p_wrong:  4.68e-7
Score:  0.311
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999993262
p_ni:  0.000006738
Data Source:  BioPlex
FBXO28
Tbio
Novelty:  0.10548865
p_int:  0.997972963
p_ni:  0.002027037
Data Source:  BioPlex
SELENBP1
Tbio
Novelty:  0.00758018
p_int:  0.946989751
p_ni:  0.053010239
p_wrong:  1e-8
Data Source:  BioPlex
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.8944741
p_ni:  0.009383829
p_wrong:  0.096142072
Score:  0.189
Data Source:  BioPlex,STRINGDB
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.78922329
p_ni:  0.210776709
p_wrong:  1e-9
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.787906687
p_ni:  0.212093313
Data Source:  BioPlex
RAB11A
Tbio
Family:  Enzyme
Novelty:  0.00153551
Score:  0.958
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
5
7
95.5
sex hormone-binding globulin measurement
6
2
5
5.8
89.7
total cholesterol measurement
4
3
4
89.5
type 2 diabetes mellitus
3
3
2
1.1
88.4
alcohol consumption measurement
4
3
4
75.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
7
95.5
sex hormone-binding globulin measurement
5
5.8
89.7
total cholesterol measurement
4
89.5
type 2 diabetes mellitus
2
1.1
88.4
alcohol consumption measurement
4
75.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
RAB11 family interacting protein 4
717629
Mouse
MGI:2442920
268451
Rat
RGD:1305063
303337
Dog
RAB11 family interacting protein 4
VGNC:45251
491159
Horse
RAB11 family interacting protein 4
VGNC:22086
100058609
Species
Name
OMA
EggNOG
Inparanoid
Macaque
RAB11 family interacting protein 4
Mouse
Rat
Dog
RAB11 family interacting protein 4
Horse
RAB11 family interacting protein 4
Publication Statistics
PubMed Score 7.61
PubMed score by year
PubTator Score 4.84
PubTator score by year
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Related Publications
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PMID
Year
Title