RAB11FIP3
Rab11 family-interacting protein 3
Protein Summary
Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. May play a role in breast cancer cell motility by regulating actin cytoskeleton. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494). Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of m ...more
- ENST00000262305
- ENSP00000262305
- ENSG00000090565
- ENST00000450428
- ENSP00000415919
- ENST00000610934
- ENSP00000484620
- ENSG00000275338
- ENST00000611004
- ENSP00000482156
- ARFO1
- KIAA0665
- CART1
- Rab11-FIP3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.79 | ||
cellular component | 0.76 | ||
transcription factor binding site profile | 0.75 | ||
transcription factor | 0.73 | ||
transcription factor perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.03 (req: < 5)
Gene RIFs: 11 (req: <= 3)
Antibodies: 86 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.03 (req: >= 5)
Gene RIFs: 11 (req: > 3)
Antibodies: 86 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (113)
Nearest Tclin Targets
Pathways (6)
Reactome (4)
KEGG (1)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo trafficking to the periciliary membrane | ||||
Reactome | Cilium Assembly | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | VxPx cargo-targeting to cilium | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo trafficking to the periciliary membrane | ||||
Cilium Assembly | ||||
Organelle biogenesis and maintenance | ||||
VxPx cargo-targeting to cilium | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (12)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | FlyBase | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (48)
Items per page:
1 – 5 of 48
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 3 | 6 | 95.3 | ||||||
heel bone mineral density | 3 | 3 | 6 | 95.3 | ||||||
mean corpuscular volume | 2 | 2 | 2 | 92.8 | ||||||
mean corpuscular volume | 2 | 2 | 2 | 92.8 | ||||||
platelet count | 2 | 2 | 2 | 90.6 | ||||||
Items per page:
1 – 5 of 48
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 6 | 95.3 | |||||
heel bone mineral density | 6 | 95.3 | |||||
mean corpuscular volume | 2 | 92.8 | |||||
mean corpuscular volume | 2 | 92.8 | |||||
platelet count | 2 | 90.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | RAB11 family interacting protein 3 | VGNC:51228 | 749821 | |||||
Macaque | RAB11 family interacting protein 3 | 722300 | ||||||
Mouse | MGI:2444431 | 215445 | ||||||
Cow | RAB11 family interacting protein 3 | VGNC:33618 | 511647 | |||||
Anole lizard | RAB11 family interacting protein 3 | 100558636 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | RAB11 family interacting protein 3 | |||||
Macaque | RAB11 family interacting protein 3 | |||||
Mouse | ||||||
Cow | RAB11 family interacting protein 3 | |||||
Anole lizard | RAB11 family interacting protein 3 | |||||
Publication Statistics
PubMed Score 9.03
PubMed score by year
PubTator Score 13.74
PubTator score by year
Related Publications
Text Mined References (33)
GeneRif Annotations (11)
Items per page:
0 of 0
PMID | Year | Title |
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