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Tbio
QTRT1
Queuine tRNA-ribosyltransferase catalytic subunit 1

Protein Summary
Description
Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (PubMed:11255023, PubMed:20354154). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product (By similarity). This gene encodes the catalytic subunit of tRNA-guanine transglycosylase. tRNA-guanine transglycosylase is a heterodimeric enzyme complex that plays a critical role in tRNA modification by synthesizing the 7-deazaguanosine queuo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000250237
  • ENSP00000250237
  • ENSG00000213339
  • ENST00000421333
  • ENSP00000389126

Symbol
  • TGT
  • TGUT
  • TGT
  • TGUT
  • FP3235
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.76
transcription factor binding site profile
0.74
tissue sample
0.7
gene perturbation
0.68
cell type or tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.72   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.72   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
THUMPD1
Tdark
Novelty:  0.19420931
p_int:  0.999998026
p_ni:  0.000001918
p_wrong:  5.6e-8
Score:  0.27
Data Source:  BioPlex,STRINGDB
NOG
Tbio
Novelty:  0.0010373
p_int:  0.999903192
p_ni:  0.000027801
p_wrong:  0.000069007
Data Source:  BioPlex
APBB2
Tbio
Novelty:  0.06546724
p_int:  0.999791913
p_ni:  0.000208065
p_wrong:  2.2e-8
Score:  0.555
Data Source:  BioPlex,STRINGDB
PRAME
Tbio
Novelty:  0.00543263
p_int:  0.986839625
p_ni:  0.012360019
p_wrong:  0.000800355
Score:  0.19
Data Source:  BioPlex,STRINGDB
APBB1
Tbio
Novelty:  0.00630564
p_int:  0.985128024
p_ni:  0.01487197
p_wrong:  6e-9
Score:  0.748
Data Source:  BioPlex,STRINGDB
PLS1
Tbio
Novelty:  0.00538817
p_int:  0.982524597
p_ni:  0.0174754
p_wrong:  4e-9
Data Source:  BioPlex
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.93192891
p_ni:  0.06807109
Score:  0.18
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.915388798
p_ni:  0.000043943
p_wrong:  0.084567259
Data Source:  BioPlex
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.760265428
p_ni:  0.239249016
p_wrong:  0.000485556
Score:  0.53
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.753174959
p_ni:  0.24682504
Score:  0.489
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
2
4
4
98.1
total cholesterol measurement
2
4
4
97.7
apolipoprotein B measurement
1
3
3
97.1
body height
3
4
4
95.7
reticulocyte measurement
3
2
3
94.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
4
98.1
total cholesterol measurement
4
97.7
apolipoprotein B measurement
3
97.1
body height
4
95.7
reticulocyte measurement
3
94.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
queuine tRNA-ribosyltransferase catalytic subunit 1
VGNC:3619
455717
Mouse
MGI:1931441
60507
Rat
RGD:620996
64016
Dog
queuine tRNA-ribosyltransferase catalytic subunit 1
VGNC:45240
476711
Horse
queuine tRNA-ribosyltransferase catalytic subunit 1
VGNC:22077
100057666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
queuine tRNA-ribosyltransferase catalytic subunit 1
Mouse
Rat
Dog
queuine tRNA-ribosyltransferase catalytic subunit 1
Horse
queuine tRNA-ribosyltransferase catalytic subunit 1
Publication Statistics
PubMed Score 21.72
PubMed score by year
PubTator Score 138.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title