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Tbio
QSOX1
Sulfhydryl oxidase 1

Protein Summary
Description
Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. May contribute to disulfide bond formation in a variety of secreted proteins. In fibroblasts, it may have tumor-suppressing capabilities being involved in growth regulation. This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367600
  • ENSP00000356572
  • ENSG00000116260
  • ENST00000367602
  • ENSP00000356574

Symbol
  • QSCN6
  • Q6
  • QSCN6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
disease perturbation
0.83
histone modification site profile
0.81
cellular component
0.69
tissue
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.27   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.27   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (289)
DDX31
Tbio
Family:  Enzyme
Novelty:  2.84646195
p_int:  0.999890509
p_ni:  0.000109489
p_wrong:  2e-9
Data Source:  BioPlex
CCL3L1
Tbio
Novelty:  0.01124082
p_int:  0.999621986
p_ni:  0.000378014
Data Source:  BioPlex
IL1R2
Tbio
Novelty:  0.00820359
p_int:  0.999453408
p_ni:  0.000546591
p_wrong:  1e-9
Score:  0.177
Data Source:  BioPlex,STRINGDB
CRP
Tbio
Novelty:  0.00001517
p_int:  0.998767534
p_ni:  0.001232412
p_wrong:  5.4e-8
Data Source:  BioPlex
FIS1
Tbio
Novelty:  0.0033607
p_int:  0.997459187
p_ni:  0.00253305
p_wrong:  0.000007763
Data Source:  BioPlex
ENSA
Tbio
Novelty:  0.01642444
p_int:  0.996501465
p_ni:  0.003498514
p_wrong:  2.1e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
GLT8D2
Tbio
Family:  Enzyme
Novelty:  0.79488367
p_int:  0.994746019
p_ni:  0.003266692
p_wrong:  0.001987289
Score:  0.201
Data Source:  BioPlex,STRINGDB
TEFM
Tbio
Novelty:  0.10836617
p_int:  0.991931456
p_ni:  0.007363764
p_wrong:  0.00070478
Data Source:  BioPlex
CST9L
Tdark
Novelty:  0.21941207
p_int:  0.988964726
p_ni:  0.010397742
p_wrong:  0.000637531
Data Source:  BioPlex
CYB5B
Tbio
Novelty:  0.09395308
p_int:  0.98880754
p_ni:  0.011177122
p_wrong:  0.000015338
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Hemostasis (R-HSA-109582)

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Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Hemostasis
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
58.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
58.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
quiescin sulfhydryl oxidase 1
VGNC:1481
457558
Mouse
MGI:1330818
104009
Rat
RGD:68957
84491
Dog
quiescin sulfhydryl oxidase 1
VGNC:45238
490299
Horse
quiescin sulfhydryl oxidase 1
VGNC:22075
100053280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
quiescin sulfhydryl oxidase 1
Mouse
Rat
Dog
quiescin sulfhydryl oxidase 1
Horse
quiescin sulfhydryl oxidase 1
Publication Statistics
PubMed Score 61.27
PubMed score by year
PubTator Score 55.63
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title