Tchem QRFPR Pyroglutamylated RF-amide peptide receptor

Protein Summary

Description

Receptor for the orexigenic neuropeptide QRFP. The activity of this receptor is mediated by G proteins that modulate adenylate cyclase activity and intracellular calcium levels.

Uniprot Accession IDs

• Q96P65

Gene Name

• QRFPR

Ensembl ID

• ENST00000394427
• ENSP00000377948
• ENSG00000186867

Symbol

• GPR103
• AQ27
• GPR103
• SP9155

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.78
cell type or tissue	0.6
molecular function	0.53
histone modification site profile	0.51
PubMedID	0.47

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Pyroglutamylated Rf-amide Peptide Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Pyroglutamylated Rfamide Peptide Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.39   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 16

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0