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Tbio
QRFP
Orexigenic neuropeptide QRFP

Protein Summary
Description
Stimulates feeding behavior, metabolic rate and locomotor activity and increases blood pressure. May have orexigenic activity. May promote aldosterone secretion by the adrenal gland (By similarity). This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. The encoded products are members of the RFamide family of neuropeptides, characterized by their common protein C-terminus consisting of an arginine (R) and an amidated phenylalanine (F). These products include the neuropeptides 26RFa and the N-terminally extended form, 43RFa. Both of these neuropeptides bind to the pyroglutamylated RFamide peptide receptor (QRFPR) and may regulate blood pressure, reproduction and food intake in rodents. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343079
  • ENSP00000345487
  • ENSG00000188710
  • ENST00000623824
  • ENSP00000485512

Symbol
  • P518
  • 26RFa
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.82
tissue sample
0.75
pathway
0.52
tissue
0.51
biological term
0.4


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.78   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 26   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.78   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 26   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (177)
QRFPR
Tchem
Family:  GPCR
Novelty:  0.03650642
Score:  0.99
Data Source:  Reactome,STRINGDB
NPFF
Tbio
Novelty:  0.00489546
Score:  0.982
Data Source:  STRINGDB
GNAQ
Tbio
Novelty:  0.0008997
Score:  0.969
Data Source:  STRINGDB
NPFFR2
Tchem
Family:  GPCR
Novelty:  0.01703886
Score:  0.969
Data Source:  STRINGDB
NPFFR1
Tchem
Family:  GPCR
Novelty:  0.01950099
Score:  0.96
Data Source:  STRINGDB
NPS
Tbio
Novelty:  0.00692108
Score:  0.957
Data Source:  STRINGDB
KISS1
Tbio
Novelty:  0.00096537
Score:  0.957
Data Source:  STRINGDB
HCRT
Tbio
Novelty:  0.00034048
Score:  0.952
Data Source:  STRINGDB
UTS2B
Tbio
Novelty:  0.04307669
Score:  0.944
Data Source:  STRINGDB
KISS1R
Tchem
Family:  GPCR
Novelty:  0.0026282
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (q) signalling events
GPCR downstream signalling
GPCR ligand binding
Orexin and neuropeptides FF and QRFP bind to their respective receptors
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
1
46.1
body height
1
1
1
35
1
1
1
33.1
insomnia measurement
1
1
0
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
46.1
body height
1
35
1
33.1
insomnia measurement
0
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyroglutamylated RFamide peptide
VGNC:13948
107976802
Mouse
MGI:3630329
227717
Rat
RGD:11442301
108348071
Dog
pyroglutamylated RFamide peptide
VGNC:45235
608592
Horse
pyroglutamylated RFamide peptide [Source:HGNC Symbol;Acc:HGNC:29982]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyroglutamylated RFamide peptide
Mouse
Rat
Dog
pyroglutamylated RFamide peptide
Horse
pyroglutamylated RFamide peptide [Source:HGNC Symbol;Acc:HGNC:29982]
Publication Statistics
PubMed Score 64.78
PubMed score by year
PubTator Score 29.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title