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Tbio
QPRT
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Protein Summary
Description
Involved in the catabolism of quinolinic acid (QA). This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000395384
  • ENSP00000378782
  • ENSG00000103485

Symbol
  • QPRTase
  • HEL-S-90n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
PubMedID
0.77
protein domain
0.73
gene perturbation
0.71
disease perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 283   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 146.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 283   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (91)
RAVER2
Tbio
Novelty:  0.35773243
p_int:  0.999999217
p_ni:  7.77e-7
p_wrong:  6e-9
Score:  0.212
Data Source:  BioPlex,STRINGDB
SATB2
Tbio
Family:  TF
Novelty:  0.00405935
p_int:  0.999989946
p_ni:  0.000010054
Data Source:  BioPlex
SATB1
Tbio
Family:  TF
Novelty:  0.00434577
p_int:  0.999986087
p_ni:  0.000009813
p_wrong:  0.0000041
Score:  0.212
Data Source:  BioPlex,STRINGDB
TRAF3IP2
Tbio
Novelty:  0.02270581
p_int:  0.999964553
p_ni:  9.03e-7
p_wrong:  0.000034544
Score:  0.345
Data Source:  BioPlex,STRINGDB
NPL
Tbio
Family:  Enzyme
Novelty:  0.00944797
p_int:  0.99996304
p_ni:  0.000035757
p_wrong:  0.000001203
Score:  0.432
Data Source:  BioPlex,STRINGDB
TRIM33
Tchem
Family:  Epigenetic
Novelty:  0.00415877
p_int:  0.999959006
p_ni:  0.000040994
Data Source:  BioPlex
IRF2BP1
Tdark
Novelty:  0.29719488
p_int:  0.999872382
p_ni:  0.00012689
p_wrong:  7.27e-7
Data Source:  BioPlex
PATL1
Tbio
Novelty:  0.10847
p_int:  0.999807741
p_ni:  0.000192259
Score:  0.212
Data Source:  BioPlex,STRINGDB
CRY2
Tbio
Novelty:  0.00156961
p_int:  0.999258559
p_ni:  0.00074081
p_wrong:  6.31e-7
Score:  0.305
Data Source:  BioPlex,STRINGDB
PER1
Tbio
Novelty:  0.01290576
p_int:  0.998886763
p_ni:  0.001113237
Score:  0.194
Data Source:  BioPlex,STRINGDB
Pathways (19)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Nicotinate metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Nicotinate metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
66
platelet count
1
1
1
10.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
66
platelet count
1
10.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1914625
67375
Rat
RGD:1310309
293504
Dog
quinolinate phosphoribosyltransferase
607664
Horse
quinolinate phosphoribosyltransferase
100065768
Cow
quinolinate phosphoribosyltransferase
614254
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
quinolinate phosphoribosyltransferase
Horse
quinolinate phosphoribosyltransferase
Cow
quinolinate phosphoribosyltransferase
Publication Statistics
PubMed Score 146.96
PubMed score by year
PubTator Score 27.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title