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Tchem
QPCT
Glutaminyl-peptide cyclotransferase

Protein Summary
Description
Responsible for the biosynthesis of pyroglutamyl peptides. Has a bias against acidic and tryptophan residues adjacent to the N-terminal glutaminyl residue and a lack of importance of chain length after the second residue. Also catalyzes N-terminal pyroglutamate formation. In vitro, catalyzes pyroglutamate formation of N-terminally truncated form of APP amyloid-beta peptides [Glu-3]-amyloid-beta. May be involved in the N-terminal pyroglutamate formation of several amyloid-related plaque-forming peptides. This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338415
  • ENSP00000344829
  • ENSG00000115828

Symbol
  • QC
  • GCT
  • sQC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
histone modification site profile
0.76
PubMedID
0.72
interacting protein
0.7
small molecule perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.92   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 208   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.92   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 373
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (127)
DHRS4
Tbio
Family:  Enzyme
Novelty:  0.02992279
p_int:  0.999977766
p_ni:  0.000022234
Score:  0.195
Data Source:  BioPlex,STRINGDB
NUBP1
Tbio
Novelty:  0.03429412
p_int:  0.998792063
p_ni:  0.001207937
Score:  0.685
Data Source:  BioPlex,STRINGDB
ELP3
Tbio
Family:  Epigenetic
Novelty:  0.0166061
p_int:  0.916233396
p_ni:  0.083766604
Score:  0.204
Data Source:  BioPlex,STRINGDB
NUBP2
Tbio
Novelty:  0.01136095
p_int:  0.759777052
p_ni:  0.240222948
Score:  0.685
Data Source:  BioPlex,STRINGDB
ACAA1
Tbio
Family:  Enzyme
Novelty:  0.00710465
Score:  0.932
Data Source:  STRINGDB
CTSD
Tchem
Family:  Enzyme
Novelty:  0.00029823
Score:  0.918
Data Source:  STRINGDB
PGLYRP1
Tbio
Novelty:  0.00231527
Score:  0.91
Data Source:  STRINGDB
LTF
Tbio
Novelty:  0.00114254
Score:  0.91
Data Source:  STRINGDB
B2M
Tbio
Novelty:  0.00011248
Score:  0.909
Data Source:  STRINGDB
LYZ
Tbio
Family:  Enzyme
Novelty:  0.00151342
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Neutrophil degranulation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
1
1
54.4
red blood cell density measurement
1
1
1
42.3
2
2
0
1.1
40.5
neutrophil percentage of leukocytes
1
1
1
39.6
body mass index
1
1
2
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte percentage of leukocytes
1
54.4
red blood cell density measurement
1
42.3
0
1.1
40.5
neutrophil percentage of leukocytes
1
39.6
body mass index
2
13.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutaminyl-peptide cyclotransferase
VGNC:377
744549
Macaque
glutaminyl-peptide cyclotransferase
712233
Mouse
MGI:1917786
70536
Dog
glutaminyl-peptide cyclotransferase
VGNC:45233
403861
Horse
glutaminyl-peptide cyclotransferase
VGNC:22071
100070174
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutaminyl-peptide cyclotransferase
Macaque
glutaminyl-peptide cyclotransferase
Mouse
Dog
glutaminyl-peptide cyclotransferase
Horse
glutaminyl-peptide cyclotransferase
Publication Statistics
PubMed Score 54.92
PubMed score by year
PubTator Score 71.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title