Protein Classes
Protein Summary
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
- ENST00000284818
- ENSP00000284818
- ENSG00000154589
- ENST00000518893
- ENSP00000430533
- ESOP1
- MD2
- MD2
- MD-2
- ly-96
- ESOP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
gene perturbation | 0.95 | ||
disease | 0.62 | ||
PubMedID | 0.59 | ||
tissue sample | 0.59 | ||
biological process | 0.57 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 629.37 (req: < 5)
Gene RIFs: 110 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 629.37 (req: >= 5)
Gene RIFs: 110 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
---|
Pathways (49)
Reactome (33)
KEGG (5)
PathwayCommons (7)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 33
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Death Receptors in the presence of ligand | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Apoptosis | ||||
Caspase activation via Death Receptors in the presence of ligand | ||||
Gene Ontology Terms (26)
Functions (4)
Components (5)
Processes (17)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (116)
1 – 10 of 116
TLR4
Novelty: 0.00013074
Score: 0.999
Data Source: Reactome,STRINGDB
LY86
Novelty: 0.00136228
Score: 0.994
Data Source: STRINGDB
TLR2
Novelty: 0.0002624
Score: 0.989
Data Source: STRINGDB
TLR1
Novelty: 0.00100796
Score: 0.982
Data Source: STRINGDB
MYD88
Novelty: 0.00054413
Score: 0.976
Data Source: Reactome,STRINGDB
CD180
Novelty: 0.02086717
Score: 0.972
Data Source: STRINGDB
TIRAP
Novelty: 0.00571157
Score: 0.967
Data Source: Reactome,STRINGDB
LBP
Novelty: 0.00228393
Score: 0.966
Data Source: STRINGDB
HMGB1
Family: TF
Novelty: 0.00050302
Score: 0.963
Data Source: Reactome,STRINGDB
S100A9
Novelty: 0.00112347
Score: 0.963
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 629.37
PubMed score by year
PubTator Score 243.95
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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