Tchem LY96 Lymphocyte antigen 96

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Lymphocyte Antigen 96

Protein Summary

Description

Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]

Uniprot Accession IDs

• Q9Y6Y9
• B3Y6A5
• E5RJJ7
• Ly-96

Gene Name

• LY96

Ensembl ID

• ENST00000284818
• ENSP00000284818
• ENSG00000154589
• ENST00000518893
• ENSP00000430533

Symbol

• ESOP1
• MD2
• MD2
• MD-2
• ly-96
• ESOP-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.95
disease	0.62
PubMedID	0.59
tissue sample	0.59
biological process	0.57

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.37   (req: < 5)

Gene RIFs: 110   (req: <= 3)

Antibodies: 458   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 629.37   (req: >= 5)

Gene RIFs: 110   (req: > 3)

Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (1)

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1 – 1 of 1

L6H21

LY96Tchem

Kd: 4.48000002

Protein Data Bank (7)

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (49)

Reactome (33)

KEGG (5)

PathwayCommons (7)

WikiPathways (4)

Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon (R-HSA-936964)

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1 – 5 of 33

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17 targets	R-HSA-936964
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Reactome	Apoptosis	177 targets	R-HSA-109581
Reactome	Caspase activation via Death Receptors in the presence of ligand	16 targets	R-HSA-140534

Name	Explore in Pharos	Explore in Source
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon	17 targets	R-HSA-936964
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing-Cross presentation	169 targets	R-HSA-1236975
Apoptosis	177 targets	R-HSA-109581
Caspase activation via Death Receptors in the presence of ligand	16 targets	R-HSA-140534

Gene Ontology Terms (26)

Functions (4)

Components (5)

Processes (17)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
lipopolysaccharide receptor activity	Inferred from Direct Assay (IDA)	UniProtKB
coreceptor activity	Traceable Author Statement (TAS)	ProtInc
lipopolysaccharide binding	Inferred from Electronic Annotation (IEA)	InterPro
Toll-like receptor 4 binding	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (116)

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1 – 10 of 116

• See Interactions on String-DB

TLR4

Tchem

Novelty: 0.00013074

Score: 0.999

Data Source: Reactome,STRINGDB

LY86

Tbio

Novelty: 0.00136228

Score: 0.994

Data Source: STRINGDB

TLR2

Tchem

Novelty: 0.0002624

Score: 0.989

Data Source: STRINGDB

TLR1

Tbio

Novelty: 0.00100796

Score: 0.982

Data Source: STRINGDB

MYD88

Tbio

Novelty: 0.00054413

Score: 0.976

Data Source: Reactome,STRINGDB

CD180

Tbio

Novelty: 0.02086717

Score: 0.972

Data Source: STRINGDB

TIRAP

Tbio

Novelty: 0.00571157

Score: 0.967

Data Source: Reactome,STRINGDB

LBP

Tbio

Novelty: 0.00228393

Score: 0.966

Data Source: STRINGDB

HMGB1

Tbio

Family: TF

Novelty: 0.00050302

Score: 0.963

Data Source: Reactome,STRINGDB

S100A9

Tbio

Novelty: 0.00112347

Score: 0.963

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  629.37

PubMed score by year

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PubTator Score  243.95

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Alternative splicing
Complete proteome
Disulfide bond
Glycoprotein
Immunity
Inflammatory response
Innate immunity
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

total cholesterol measurement

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
immune system phenotype