Protein Classes
Protein Summary
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
- ENST00000284818
- ENSP00000284818
- ENSG00000154589
- ENST00000518893
- ENSP00000430533
- ESOP1
- MD2
- MD2
- MD-2
- ly-96
- ESOP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
disease | 0.62 | ||
PubMedID | 0.59 | ||
tissue sample | 0.59 | ||
biological process | 0.57 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 734.86 (req: < 5)
Gene RIFs: 110 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 734.86 (req: >= 5)
Gene RIFs: 110 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (1)
1 – 1 of 1
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 96 | VGNC:852 | 746178 | |||||
Macaque | lymphocyte antigen 96 | 696778 | ||||||
Mouse | MGI:1341909 | 17087 | ||||||
Dog | lymphocyte antigen 96 | VGNC:42878 | 610524 | |||||
Horse | lymphocyte antigen 96 | VGNC:19848 | 100034040 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 96 | |||||
Macaque | lymphocyte antigen 96 | |||||
Mouse | ||||||
Dog | lymphocyte antigen 96 | |||||
Horse | lymphocyte antigen 96 | |||||
Protein Structure (7 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 7
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (49)
Reactome (33)
KEGG (5)
PathwayCommons (7)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 33
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Death Receptors in the presence of ligand | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Apoptosis | ||||
Caspase activation via Death Receptors in the presence of ligand | ||||
Gene Ontology Terms (26)
Functions (4)
Components (5)
Processes (17)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (116)
1 – 10 of 116
TLR4
Novelty: 0.00010863
Score: 0.999
Data Source: Reactome,STRINGDB
LY86
Novelty: 0.00314575
Score: 0.994
Data Source: STRINGDB
TLR2
Novelty: 0.00023242
Score: 0.989
Data Source: STRINGDB
TLR1
Novelty: 0.00171909
Score: 0.982
Data Source: STRINGDB
MYD88
Novelty: 0.00037931
Score: 0.976
Data Source: Reactome,STRINGDB
CD180
Novelty: 0.01839955
Score: 0.972
Data Source: STRINGDB
TIRAP
Novelty: 0.00600495
Score: 0.967
Data Source: Reactome,STRINGDB
LBP
Novelty: 0.00185354
Score: 0.966
Data Source: STRINGDB
HMGB1
Family: TF
Novelty: 0.00043845
Score: 0.963
Data Source: Reactome,STRINGDB
S100A9
Novelty: 0.00185141
Score: 0.963
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 734.86
PubMed score by year
PubTator Score 243.95
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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