Protein Summary
Binds bacterial lipopolysaccharide (LPS) (PubMed:17803912, PubMed:17569869). Cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS), and with TLR2 in the response to cell wall components from Gram-positive and Gram-negative bacteria (PubMed:11160242, PubMed:11593030). Enhances TLR4-dependent activation of NF-kappa-B (PubMed:10359581). Cells expressing both LY96 and TLR4, but not TLR4 alone, respond to LPS (PubMed:10359581). This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2010]
- ENST00000284818
- ENSP00000284818
- ENSG00000154589
- ENST00000518893
- ENSP00000430533
- ESOP1
- MD2
- MD2
- MD-2
- ly-96
- ESOP-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.95 | ||
disease | 0.62 | ||
PubMedID | 0.59 | ||
tissue sample | 0.59 | ||
biological process | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 753.83 (req: < 5)
Gene RIFs: 110 (req: <= 3)
Antibodies: 458 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 753.83 (req: >= 5)
Gene RIFs: 110 (req: > 3)
Antibodies: 458 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 21
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (116)
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (49)
Reactome (33)
KEGG (5)
PathwayCommons (7)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing-Cross presentation | ||||
Reactome | Apoptosis | ||||
Reactome | Caspase activation via Death Receptors in the presence of ligand | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon | ||||
Adaptive Immune System | ||||
Antigen processing-Cross presentation | ||||
Apoptosis | ||||
Caspase activation via Death Receptors in the presence of ligand | ||||
Viral Interactions (0)
Gene Ontology Terms (26)
Functions (4)
Components (5)
Processes (17)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 1 | 1 | 47.7 | |||||
alkaline phosphatase measurement | 1 | 1 | 1 | 45.7 | |||||
total cholesterol measurement | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
low density lipoprotein cholesterol measurement | 1 | 47.7 | |||||
alkaline phosphatase measurement | 1 | 45.7 | |||||
total cholesterol measurement | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 96 | VGNC:852 | 746178 | |||||
Macaque | lymphocyte antigen 96 | 696778 | ||||||
Mouse | MGI:1341909 | 17087 | ||||||
Dog | lymphocyte antigen 96 | VGNC:42878 | 610524 | |||||
Horse | lymphocyte antigen 96 | VGNC:19848 | 100034040 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lymphocyte antigen 96 | |||||
Macaque | lymphocyte antigen 96 | |||||
Mouse | ||||||
Dog | lymphocyte antigen 96 | |||||
Horse | lymphocyte antigen 96 | |||||
Publication Statistics
PubMed Score 753.83
PubMed score by year
PubTator Score 243.95
PubTator score by year
Related Publications
Text Mined References (130)
GeneRif Annotations (110)
Items per page:
0 of 0
PMID | Year | Title |
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