Tbio ENPP4 Bis(5'-adenosyl)-triphosphatase ENPP4

Protein Summary

Description

Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.

Uniprot Accession IDs

• Q9Y6X5
• A8K5G1
• Q7L2N1

Gene Name

• ENPP4

Ensembl ID

• ENST00000321037
• ENSP00000318066
• ENSG00000001561

Symbol

• KIAA0879
• NPP4
• NPP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.8
protein domain	0.73
microRNA	0.68
disease perturbation	0.62
kinase perturbation	0.6

Protein Classes

PANTHER Classes

Protein / Hydrolase / Pyrophosphatase / Bis(5'-adenosyl)-triphosphatase Enpp4

Protein / Hydrolase / Phosphatase / Nucleotide Phosphatase / Bis(5'-adenosyl)-triphosphatase Enpp4

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Nucleotide Phosphatase / Bis(5'-adenosyl)-triphosphatase Enpp4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 112   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.98   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 112   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0