Tbio MAU2 MAU2 chromatid cohesion factor homolog

Protein Summary

Description

Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:28167679, PubMed:22628566). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16802858, PubMed:16682347).

Uniprot Accession IDs

• Q9Y6X3
• Q66PT1
• Q6P3S7
• Q6ZTT2
• Q9UFX8
• MAU-2

Gene Name

• MAU2

Ensembl ID

• ENST00000262815
• ENSP00000262815
• ENSG00000129933

Symbol

• KIAA0892
• SCC4
• SCC4
• MAU2L
• mau-2
• KIAA0892

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.91
transcription factor perturbation	0.84
transcription factor binding site profile	0.81
disease perturbation	0.74
kinase perturbation	0.66

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.18   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 42   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 189.18   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 42   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0