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Tbio
PIAS3
E3 SUMO-protein ligase PIAS3

Protein Summary
Description
Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376). This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393045
  • ENSP00000376765
  • ENSG00000131788

Symbol
  • ZMIZ5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
hub protein
0.88
disease perturbation
0.87
transcription factor binding site profile
0.68
molecular function
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.79   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
2
4
4
91.9
myeloid white cell count
1
1
1
68.8
high density lipoprotein cholesterol measurement
1
2
2
54.2
apolipoprotein A 1 measurement
1
2
2
52.3
granulocyte count
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
4
91.9
myeloid white cell count
1
68.8
high density lipoprotein cholesterol measurement
2
54.2
apolipoprotein A 1 measurement
2
52.3
granulocyte count
1
46.9
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein inhibitor of activated STAT 3
VGNC:6135
457223
Macaque
protein inhibitor of activated STAT 3
706775
Mouse
MGI:1913126
229615
Rat
RGD:708413
83614
Dog
protein inhibitor of activated STAT 3
VGNC:44521
483160
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein inhibitor of activated STAT 3
Macaque
protein inhibitor of activated STAT 3
Mouse
Rat
Dog
protein inhibitor of activated STAT 3
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6X2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (35)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Formation of Incision Complex in GG-NER
Reactome
Global Genome Nucleotide Excision Repair (GG-NER)
Reactome
Metabolism of proteins
Reactome
Nucleotide Excision Repair
Name
Explore in Pharos
Explore in Source
DNA Repair
Formation of Incision Complex in GG-NER
Global Genome Nucleotide Excision Repair (GG-NER)
Metabolism of proteins
Nucleotide Excision Repair
Gene Ontology Terms (20)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (125)
1 – 10 of 125
UBE2I
Tbio
Novelty:  0.00267883
Score:  0.996
Data Source:  STRINGDB
SUMO1
Tbio
Novelty:  0.00137629
Score:  0.986
Data Source:  STRINGDB
SUMO2
Tbio
Novelty:  0.00366833
Score:  0.985
Data Source:  STRINGDB
STAT3
Tchem
Family:  TF
Novelty:  0.00011808
Score:  0.982
Data Source:  STRINGDB
SUMO3
Tbio
Novelty:  0.03096465
Score:  0.97
Data Source:  STRINGDB
MITF
Tchem
Family:  TF
Novelty:  0.00094044
Score:  0.962
Data Source:  STRINGDB
SMAD3
Tchem
Family:  TF
Novelty:  0.00048058
Score:  0.956
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.954
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.952
Data Source:  STRINGDB
JAK1
Tclin
Family:  Kinase
Novelty:  0.00093625
Score:  0.949
Data Source:  STRINGDB
Publication Statistics
PubMed Score  74.79

PubMed score by year
PubTator Score  64.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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