Tbio SERP1 Stress-associated endoplasmic reticulum protein 1

Protein Summary

Description

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).

Uniprot Accession IDs

• Q9Y6X1
• D3DNI6

Gene Name

• SERP1

Ensembl ID

• ENST00000239944
• ENSP00000239944
• ENSG00000120742
• ENST00000479209
• ENSP00000420076

Symbol

• RAMP4
• RAMP4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
co-expressed gene	0.97
transcription factor perturbation	0.97
biological process	0.92
virus perturbation	0.92

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Stress-associated Endoplasmic Reticulum Protein 1

Protein / Chaperone / Stress-associated Endoplasmic Reticulum Protein 1

DTO Classes

Protein / Nucleic Acid Binding / Rna Binding Protein / Ribosomal Protein / Stress-associated Endoplasmic Reticulum Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.35   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.35   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0