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Tbio
SERP1
Stress-associated endoplasmic reticulum protein 1

Protein Summary
Description
Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239944
  • ENSP00000239944
  • ENSG00000120742
  • ENST00000479209
  • ENSP00000420076

Symbol
  • RAMP4
  • RAMP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.97
transcription factor perturbation
0.97
biological process
0.92
virus perturbation
0.92


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.58   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.58   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stress associated endoplasmic reticulum protein 1
VGNC:14232
460778
Macaque
stress associated endoplasmic reticulum protein 1
106997040
Mouse
MGI:92638
28146
Rat
RGD:620790
80881
Cow
stress associated endoplasmic reticulum protein 1
VGNC:34464
528100
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stress associated endoplasmic reticulum protein 1
Macaque
stress associated endoplasmic reticulum protein 1
Mouse
Rat
Cow
stress associated endoplasmic reticulum protein 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6X1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
IRE1alpha activates chaperones (R-HSA-381070)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
IRE1alpha activates chaperones
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Metabolism of proteins
Reactome
Protein localization
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
IRE1alpha activates chaperones
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Metabolism of proteins
Protein localization
Unfolded Protein Response (UPR)
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (44)
1 – 10 of 44
SEC61B
Tbio
Novelty: 0.08622222
Score: 0.983
Data Source: STRINGDB
SEC61A1
Tbio
Novelty: 0.0026034
Score: 0.974
Data Source: STRINGDB
SEC61G
Tbio
Novelty: 0.11375671
Score: 0.959
Data Source: STRINGDB
ASNA1
Tbio
Family: Enzyme
Novelty: 0.01260233
Score: 0.955
Data Source: STRINGDB
SEC62
Tbio
Novelty: 0.01236418
Score: 0.954
Data Source: STRINGDB
SEC61A2
Tdark
Novelty: 1.46395791
Score: 0.945
Data Source: STRINGDB
SEC63
Tbio
Novelty: 0.00974614
Score: 0.945
Data Source: STRINGDB
SPCS1
Tbio
Family: Enzyme
Novelty: 0.0731223
Score: 0.676
Data Source: STRINGDB
SEC11C
Tdark
Family: Enzyme
Novelty: 0.19577003
Score: 0.672
Data Source: STRINGDB
DAD1
Tbio
Family: Enzyme
Novelty: 0.00653242
Score: 0.642
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.58

PubMed score by year
PubTator Score  17.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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