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Tbio
ICOS
Inducible T-cell costimulator

Protein Summary
Description
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes (By similarity). The protein encoded by this gene belongs to the CD28 and CTLA-4 cell-surface receptor family. It forms homodimers and plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316386
  • ENSP00000319476
  • ENSG00000163600
  • ENST00000435193
  • ENSP00000415951

Symbol
  • AILIM
  • AILIM
  • CD278
  • CVID1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.74
microRNA
0.72
disease
0.63
tissue sample
0.61
gene perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.76   (req: < 5)
Gene RIFs: 111   (req: <= 3)
Antibodies: 894   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.76   (req: >= 5)
Gene RIFs: 111   (req: > 3)
Antibodies: 894   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (90)
1 – 10 of 90
ICOSLG
Tbio
Novelty:  0.00693966
p_int:  0.999998263
p_ni:  3.54e-7
p_wrong:  0.000001383
Score:  0.966
Data Source:  BioPlex,Reactome,STRINGDB
MELTF
Tbio
Novelty:  0.00853228
p_int:  0.997462923
p_ni:  2.27e-7
p_wrong:  0.002536851
Score:  0.692
Data Source:  BioPlex,STRINGDB
RC3H1
Tbio
Novelty:  0.02346598
Score:  0.947
Data Source:  STRINGDB
CD40LG
Tbio
Novelty:  0.00032058
Score:  0.933
Data Source:  STRINGDB
PIK3R1
Tchem
Family:  Kinase
Novelty:  0.00179772
Score:  0.889
Data Source:  Reactome,STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
Score:  0.824
Data Source:  STRINGDB
PIK3CD
Tclin
Family:  Kinase
Novelty:  0.00572779
Score:  0.821
Data Source:  STRINGDB
PIK3R2
Tbio
Family:  Enzyme
Novelty:  0.00829659
Score:  0.818
Data Source:  STRINGDB
PIK3R3
Tbio
Family:  Enzyme
Novelty:  0.0136069
Score:  0.818
Data Source:  STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
Score:  0.805
Data Source:  Reactome,STRINGDB
Pathways (245)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Costimulation by the CD28 family
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Constitutive Signaling by Aberrant PI3K in Cancer
Costimulation by the CD28 family
Disease
Diseases of signal transduction
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
2
2
0
1.3
88.5
serum non-albumin protein measurement
1
3
3
86.2
3
2
0
1.4
76.6
2
2
0
1.4
74.5
2
2
1
1.1
74.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
autoimmune thyroid disease
0
1.3
88.5
serum non-albumin protein measurement
3
86.2
0
1.4
76.6
0
1.4
74.5
1
1.1
74.1
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inducible T cell costimulator
VGNC:10846
747295
Macaque
inducible T-cell costimulator
705788
Mouse
MGI:1858745
54167
Rat
RGD:620123
64545
Dog
inducible T cell costimulator
VGNC:41861
403456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inducible T cell costimulator
Macaque
inducible T-cell costimulator
Mouse
Rat
Dog
inducible T cell costimulator
Publication Statistics
PubMed Score 63.76
PubMed score by year
PubTator Score 257.94
PubTator score by year