Tbio WASF2 Wiskott-Aldrich syndrome protein family member 2

Protein Summary

Description

Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q9Y6W5
• B4DZN0
• O60794
• Q9UDY7
• WASP family protein member 2

Gene Name

• WASF2

Ensembl ID

• ENST00000536657
• ENSP00000439883
• ENSG00000158195
• ENST00000618852
• ENSP00000483313

Symbol

• WAVE2
• IMD2
• SCAR2
• WASF4
• WAVE2
• dJ393P12.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.92
transcription factor binding site profile	0.91
cell type or tissue	0.86
microRNA	0.85
transcription factor	0.83

Protein Classes

PANTHER Classes

Protein / Cytoskeletal Protein / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 2

DTO Classes

Protein / Cellular Structure / Actin Family Cytoskeletal Protein / Non-motor Actin Binding Protein / Wiskott-aldrich Syndrome Protein Family Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.87   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 313   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 169.87   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0