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Tbio
WASF2
Wiskott-Aldrich syndrome protein family member 2

Protein Summary
Description
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different iso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536657
  • ENSP00000439883
  • ENSG00000158195
  • ENST00000618852
  • ENSP00000483313

Symbol
  • WAVE2
  • IMD2
  • SCAR2
  • WASF4
  • WAVE2
  • dJ393P12.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
transcription factor binding site profile
0.91
cell type or tissue
0.86
microRNA
0.85
transcription factor
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.94   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.94   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Calcium channel blocker use measurement
1
1
1
0.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Calcium channel blocker use measurement
1
0.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1098641
242687
Rat
RGD:1307299
313024
Dog
WAS protein family member 2
VGNC:48334
487343
Cow
WAS protein family member 2
VGNC:36866
504482
Opossum
WAS protein family member 2
100618879
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
WAS protein family member 2
Cow
WAS protein family member 2
Opossum
WAS protein family member 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6W5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (75)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Gene Ontology Terms (30)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (157)
1 – 10 of 157
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999999756
p_ni:  2.43e-7
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,STRINGDB
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999999203
p_ni:  7.97e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999999164
p_ni:  8.36e-7
Score:  0.994
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999997741
p_ni:  0.000002259
Score:  0.579
Data Source:  BioPlex,STRINGDB
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.999941189
p_ni:  0.000058811
Score:  0.963
Data Source:  BioPlex,STRINGDB
TIMM50
Tbio
Family:  Enzyme
Novelty:  0.0238053
p_int:  0.999850972
p_ni:  0.000149028
Score:  0.173
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999748334
p_ni:  0.000251666
Data Source:  BioPlex
EPS8L1
Tbio
Family:  Enzyme
Novelty:  0.15959644
p_int:  0.998778755
p_ni:  0.001221245
Data Source:  BioPlex
NHSL2
Tdark
Novelty:  4.36275023
p_int:  0.99839334
p_ni:  0.001606658
p_wrong:  2e-9
Score:  0.708
Data Source:  BioPlex,STRINGDB
ZNF511
Tdark
Novelty:  1.07235474
p_int:  0.998218538
p_ni:  0.001781462
Score:  0.416
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  110.94

PubMed score by year
PubTator Score  646.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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