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Tbio
WASF2
Wiskott-Aldrich syndrome protein family member 2

Protein Summary
Description
Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different iso ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000536657
  • ENSP00000439883
  • ENSG00000158195
  • ENST00000618852
  • ENSP00000483313

Symbol
  • WAVE2
  • IMD2
  • SCAR2
  • WASF4
  • WAVE2
  • dJ393P12.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
transcription factor binding site profile
0.91
cell type or tissue
0.86
microRNA
0.85
transcription factor
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.36   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 399.36   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (75)
Fcgamma receptor (FCGR) dependent phagocytosis (R-HSA-2029480)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fcgamma receptor (FCGR) dependent phagocytosis
Reactome
Immune System
Reactome
Innate Immune System
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases Activate WASPs and WAVEs
Name
Explore in Pharos
Explore in Source
Fcgamma receptor (FCGR) dependent phagocytosis
Immune System
Innate Immune System
RHO GTPase Effectors
RHO GTPases Activate WASPs and WAVEs
Protein-Protein Interactions (157)
1 – 10 of 157
BRK1
Tbio
Novelty: 0.03479369
p_int: 0.999999756
p_ni: 2.43e-7
p_wrong: 1e-9
Score: 0.994
Data Source: BioPlex,STRINGDB
NCKAP1
Tbio
Novelty: 0.06198423
p_int: 0.999999203
p_ni: 7.97e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ABI2
Tbio
Novelty: 0.03279246
p_int: 0.999999164
p_ni: 8.36e-7
Score: 0.994
Data Source: BioPlex,STRINGDB
NCK2
Tbio
Novelty: 0.02908657
p_int: 0.999997741
p_ni: 0.000002259
Score: 0.579
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00554007
p_int: 0.999941189
p_ni: 0.000058811
Score: 0.963
Data Source: BioPlex,STRINGDB
TIMM50
Tbio
Family: Enzyme
Novelty: 0.03118503
p_int: 0.999850972
p_ni: 0.000149028
Score: 0.173
Data Source: BioPlex,STRINGDB
ARHGAP12
Tbio
Family: Enzyme
Novelty: 0.162065
p_int: 0.999748334
p_ni: 0.000251666
Data Source: BioPlex
EPS8L1
Tbio
Family: Enzyme
Novelty: 0.68126521
p_int: 0.998778755
p_ni: 0.001221245
Data Source: BioPlex
NHSL2
Tdark
Novelty: 0.36363636
p_int: 0.99839334
p_ni: 0.001606658
p_wrong: 2e-9
Score: 0.708
Data Source: BioPlex,STRINGDB
ZNF511
Tdark
Novelty: 1.82068966
p_int: 0.998218538
p_ni: 0.001781462
Score: 0.416
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  399.36

PubMed score by year
PubTator Score  646.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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