Tbio PCLO Protein piccolo

Protein Summary

Description

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q9Y6V0
• A4D1A7
• A6NNX9
• O43373
• O60305
• Q08E72
• Q9BVC8
• Q9UIV2
• Q9Y6U9

Gene Name

• PCLO

Ensembl ID

• ENST00000333891
• ENSP00000334319
• ENSG00000186472
• ENST00000423517
• ENSP00000388393
• ENST00000618073
• ENSP00000482390

Symbol

• ACZ
• KIAA0559
• ACZ
• PCH3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.96
kinase	0.94
cellular component	0.8
PubMedID	0.77
histone modification site profile	0.74

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (1)

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (1)

KEGG (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Insulin secretion	89 targets	path:hsa04911

Name	Explore in Pharos	Explore in Source
Insulin secretion	89 targets	path:hsa04911

Gene Ontology Terms (19)

Functions (4)

Components (6)

Processes (9)

Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
calcium ion binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
calcium-dependent phospholipid binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
profilin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
structural constituent of presynaptic active zone	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (72)

Explore Interacting Targets

1 – 10 of 72

• See Interactions on String-DB

RAPGEF4

Tchem

Novelty: 0.00312338

Score: 0.96

Data Source: STRINGDB

RIMS2

Tbio

Novelty: 0.01863266

Score: 0.915

Data Source: STRINGDB

RAB3A

Tbio

Family: Enzyme

Novelty: 0.00506015

Score: 0.889

Data Source: STRINGDB