Tbio PCLO Protein piccolo

Protein Summary

Description

May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Accession IDs

• Q9Y6V0
• A4D1A7
• A6NNX9
• O43373
• O60305
• Q08E72
• Q9BVC8
• Q9UIV2
• Q9Y6U9

Gene Name

• PCLO

Ensembl ID

• ENST00000333891
• ENSP00000334319
• ENSG00000186472
• ENST00000423517
• ENSP00000388393
• ENST00000618073
• ENSP00000482390

Symbol

• ACZ
• KIAA0559
• ACZ
• PCH3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.96
kinase	0.94
cellular component	0.8
PubMedID	0.77
histone modification site profile	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.48   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 228   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 209.48   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0