PCLO
Protein piccolo
Protein Summary
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
- ENST00000333891
- ENSP00000334319
- ENSG00000186472
- ENST00000423517
- ENSP00000388393
- ENST00000618073
- ENSP00000482390
- ACZ
- KIAA0559
- ACZ
- PCH3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
microRNA | 0.96 | ||
kinase | 0.94 | ||
cellular component | 0.8 | ||
PubMedID | 0.77 | ||
histone modification site profile | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.48 (req: < 5)
Gene RIFs: 31 (req: <= 3)
Antibodies: 228 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 209.48 (req: >= 5)
Gene RIFs: 31 (req: > 3)
Antibodies: 228 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0