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Tbio
PCLO
Protein piccolo

Protein Summary
Description
May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking. The protein encoded by this gene is part of the presynaptic cytoskeletal matrix, which is involved in establishing active synaptic zones and in synaptic vesicle trafficking. Variations in this gene have been associated with bipolar disorder and major depressive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333891
  • ENSP00000334319
  • ENSG00000186472
  • ENST00000423517
  • ENSP00000388393
  • ENST00000618073
  • ENSP00000482390

Symbol
  • ACZ
  • KIAA0559
  • ACZ
  • PCH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.96
kinase
0.94
cellular component
0.8
PubMedID
0.77
histone modification site profile
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 228   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 304.08   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 228   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (72)
1 – 10 of 72
RAPGEF4
Tchem
Novelty: 0.00312338
Score: 0.96
Data Source: STRINGDB
RIMS2
Tbio
Novelty: 0.01863266
Score: 0.915
Data Source: STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.00506015
Score: 0.889
Data Source: STRINGDB