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Tbio
DGKB
Diacylglycerol kinase beta

Protein Summary
Description
Exhibits high phosphorylation activity for long-chain diacylglycerols. Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399322
  • ENSP00000382260
  • ENSG00000136267
  • ENST00000403951
  • ENSP00000385780
  • ENST00000406247
  • ENSP00000386066

Symbol
  • DAGK2
  • KIAA0718
  • DGK
  • DAGK2
  • DGK-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
microRNA
0.94
molecular function
0.94
metabolite
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.43   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.43   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
4
90.5
6
1
2
1.1
88.9
cup-to-disc ratio measurement
3
2
4
76
BMI-adjusted waist-hip ratio
1
1
1
72.6
testosterone measurement
3
1
3
65.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
90.5
2
1.1
88.9
cup-to-disc ratio measurement
4
76
BMI-adjusted waist-hip ratio
1
72.6
testosterone measurement
3
65.1
Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
CDS2
Tbio
Family: Enzyme
Novelty: 0.13210626
Score: 0.87
Data Source: STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.08094799
Score: 0.835
Data Source: STRINGDB
PLCB4
Tbio
Family: Enzyme
Novelty: 0.01840915
Score: 0.751
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.01820899
Score: 0.748
Data Source: STRINGDB
AGPAT2
Tchem
Family: Enzyme
Novelty: 0.01321334
Score: 0.74
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00331129
Score: 0.739
Data Source: STRINGDB
AGMO
Tbio
Family: Enzyme
Novelty: 0.03595131
Score: 0.737
Data Source: STRINGDB
MOGAT1
Tbio
Family: Enzyme
Novelty: 0.0503068
Score: 0.737
Data Source: STRINGDB
PLCB3
Tbio
Family: Enzyme
Novelty: 0.01388454
Score: 0.737
Data Source: STRINGDB
CHPT1
Tbio
Family: Enzyme
Novelty: 0.02875977
Score: 0.729
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.43

PubMed score by year
PubTator Score  215.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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