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Tbio
DGKB
Diacylglycerol kinase beta

Protein Classes
Protein Summary
Description
Exhibits high phosphorylation activity for long-chain diacylglycerols. Diacylglycerol kinases (DGKs) are regulators of the intracellular concentration of the second messenger diacylglycerol (DAG) and thus play a key role in cellular processes. Nine mammalian isotypes have been identified, which are encoded by separate genes. Mammalian DGK isozymes contain a conserved catalytic (kinase) domain and a cysteine-rich domain (CRD). The protein encoded by this gene is a diacylglycerol kinase, beta isotype. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399322
  • ENSP00000382260
  • ENSG00000136267
  • ENST00000403951
  • ENSP00000385780
  • ENST00000406247
  • ENSP00000386066

Symbol
  • DAGK2
  • KIAA0718
  • DGK
  • DAGK2
  • DGK-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
trait
0.97
microRNA
0.94
molecular function
0.94
metabolite
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.35   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.35   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
6
5
1.1
97.4
glucose measurement
4
6
6
97
fasting blood glucose measurement
9
4
10
92.6
testosterone measurement
4
2
4
87.8
body mass index
2
2
2
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
97.4
glucose measurement
6
97
fasting blood glucose measurement
10
92.6
testosterone measurement
4
87.8
body mass index
2
74
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase beta
VGNC:4330
463271
Macaque
diacylglycerol kinase beta
715254
Mouse
MGI:2442474
217480
Rat
RGD:2488
54248
Dog
diacylglycerol kinase beta
VGNC:39916
482328
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diacylglycerol kinase beta
Macaque
diacylglycerol kinase beta
Mouse
Rat
Dog
diacylglycerol kinase beta
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6T7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (117)
1 – 10 of 117
CDS2
Tbio
Family:  Enzyme
Novelty:  0.13210626
Score:  0.87
Data Source:  STRINGDB
CDS1
Tbio
Family:  Enzyme
Novelty:  0.08094799
Score:  0.835
Data Source:  STRINGDB
PLCB4
Tbio
Family:  Enzyme
Novelty:  0.01840915
Score:  0.751
Data Source:  STRINGDB
MBOAT2
Tbio
Family:  Enzyme
Novelty:  0.01820899
Score:  0.748
Data Source:  STRINGDB
AGPAT2
Tchem
Family:  Enzyme
Novelty:  0.01321334
Score:  0.74
Data Source:  STRINGDB
PLD2
Tchem
Family:  Enzyme
Novelty:  0.00331129
Score:  0.739
Data Source:  STRINGDB
AGMO
Tbio
Family:  Enzyme
Novelty:  0.03595131
Score:  0.737
Data Source:  STRINGDB
MOGAT1
Tbio
Family:  Enzyme
Novelty:  0.0503068
Score:  0.737
Data Source:  STRINGDB
PLCB3
Tbio
Family:  Enzyme
Novelty:  0.01388454
Score:  0.737
Data Source:  STRINGDB
CHPT1
Tbio
Family:  Enzyme
Novelty:  0.02875977
Score:  0.729
Data Source:  STRINGDB
Publication Statistics
PubMed Score  44.35

PubMed score by year
PubTator Score  215.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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