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Tdark
RPS6KL1
Ribosomal protein S6 kinase-like 1

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354625
  • ENSP00000346644
  • ENSG00000198208
  • ENST00000555009
  • ENSP00000450660
  • ENST00000555647
  • ENSP00000452027
  • ENST00000557413
  • ENSP00000450567

Symbol
  • RSKL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.9
tissue sample
0.68
cell line
0.63
transcription factor
0.58
cellular component
0.55


Related Tools
Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.55   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
1
2
0
5.8
73.1
worry measurement
1
1
1
72
high density lipoprotein cholesterol measurement
1
1
1
38.8
blood protein measurement
1
1
1
4.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
0
5.8
73.1
worry measurement
1
72
high density lipoprotein cholesterol measurement
1
38.8
blood protein measurement
1
4.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase like 1
VGNC:3321
741779
Macaque
ribosomal protein S6 kinase like 1
701119
Mouse
MGI:2443413
238323
Rat
RGD:1309493
299202
Dog
ribosomal protein S6 kinase like 1
VGNC:45747
100856462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein S6 kinase like 1
Macaque
ribosomal protein S6 kinase like 1
Mouse
Rat
Dog
ribosomal protein S6 kinase like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6S9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (20)
1 – 10 of 20
MED30
Tbio
Family: Enzyme
Novelty: 0.08618054
p_int: 0.903329945
p_ni: 0.096665209
p_wrong: 0.000004846
Data Source: BioPlex
ZNF710
Tdark
Family: TF
Novelty: 0.86325831
Score: 0.84
Data Source: STRINGDB
ZNF541
Tdark
Family: TF
Novelty: 1.64949592
Score: 0.815
Data Source: STRINGDB
ZNF524
Tdark
Family: TF
Novelty: 2.44930764
Score: 0.746
Data Source: STRINGDB
POLD1
Tclin
Family: Enzyme
Novelty: 0.00508209
Score: 0.709
Data Source: STRINGDB
MAPK7
Tchem
Family: Kinase
Novelty: 0.00257226
Score: 0.598
Data Source: STRINGDB
DCAF12L2
Tdark
Novelty: 2.92107204
Score: 0.561
Data Source: STRINGDB
S100B
Tchem
Novelty: 0.00031007
Score: 0.553
Data Source: STRINGDB
ADGRD1
Tbio
Family: GPCR
Novelty: 0.08106046
Score: 0.519
Data Source: STRINGDB
TRIM42
Tdark
Novelty: 0.21068414
Score: 0.501
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.55

PubMed score by year
PubTator Score  0.12

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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