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Tbio
MAP3K4
Mitogen-activated protein kinase kinase kinase 4

Protein Summary
Description
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6. The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366919
  • ENSP00000355886
  • ENSG00000085511
  • ENST00000392142
  • ENSP00000375986

Symbol
  • KIAA0213
  • MAPKKK4
  • MEKK4
  • MTK1
  • MTK1
  • MEKK4
  • MEKK 4
  • MAPKKK4
  • PRO0412
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.99
disease perturbation
0.93
histone modification site profile
0.83
biological process
0.8


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.22   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 4
710360
Mouse
MGI:1346875
26407
Rat
RGD:1311192
308106
Dog
mitogen-activated protein kinase kinase kinase 4
VGNC:42974
476262
Horse
mitogen-activated protein kinase kinase kinase 4
VGNC:19938
100058153
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 4
Mouse
Rat
Dog
mitogen-activated protein kinase kinase kinase 4
Horse
mitogen-activated protein kinase kinase kinase 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6R4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (79)
1 – 10 of 79
GADD45B
Tbio
Novelty: 0.00611526
p_int: 1
Score: 0.983
Data Source: BioPlex,STRINGDB
GADD45G
Tbio
Novelty: 0.00436103
p_int: 0.999999964
p_ni: 3.6e-8
Score: 0.986
Data Source: BioPlex,STRINGDB
GADD45A
Tbio
Novelty: 0.00178533
p_int: 0.99999976
p_ni: 2.4e-7
Score: 0.971
Data Source: BioPlex,STRINGDB
SPATA1
Tdark
p_int: 0.999999127
p_ni: 8.73e-7
Data Source: BioPlex
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.999973478
p_ni: 0.000026521
Score: 0.177
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.999930518
p_ni: 0.000069482
Score: 0.179
Data Source: BioPlex,STRINGDB
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.998997672
p_ni: 0.001002328
Score: 0.231
Data Source: BioPlex,STRINGDB
SIGLECL1
Tdark
p_int: 0.996450065
p_ni: 0.003549918
p_wrong: 1.7e-8
Data Source: BioPlex
BTK
Tclin
Family: Kinase
Novelty: 0.00050747
p_int: 0.971403551
p_ni: 0.027923846
p_wrong: 0.000672603
Score: 0.388
Data Source: BioPlex,STRINGDB
MAP2K6
Tchem
Family: Kinase
Novelty: 0.00569655
Score: 0.976
Data Source: STRINGDB
Publication Statistics
PubMed Score  43.22

PubMed score by year
PubTator Score  64.11

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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