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Tbio
SLC4A4
Electrogenic sodium bicarbonate cotransporter 1

Protein Summary
Description
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH. Isoform 2: May have a higher activity than isoform 1. This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264485
  • ENSP00000264485
  • ENSG00000080493
  • ENST00000340595
  • ENSP00000344272
  • ENST00000351898
  • ENSP00000307349
  • ENST00000425175
  • ENSP00000393557
  • ENST00000512686
  • ENSP00000422400
  • ENST00000649996
  • ENSP00000497468

Symbol
  • NBC
  • NBC1
  • NBCE1
  • KNBC
  • NBC1
  • NBC2
  • pNBC
  • HNBC1
  • hhNMC
  • kNBC1
  • SLC4A5
  • NBCe1-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.96
disease perturbation
0.87
molecular function
0.86
small molecule perturbation
0.84
histone modification site profile
0.79


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.82   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 165   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 315.82   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 165   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
9
8
6.3
99.9
heel bone mineral density
3
1
3
85.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
8
6.3
99.9
heel bone mineral density
3
85.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 4
VGNC:7720
461271
Macaque
solute carrier family 4 member 4
705830
Mouse
MGI:1927555
54403
Rat
RGD:68936
84484
Dog
solute carrier family 4 member 4
VGNC:46434
475171
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 4
Macaque
solute carrier family 4 member 4
Mouse
Rat
Dog
solute carrier family 4 member 4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6R1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
SLC transporter disorders
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Disease
Disorders of transmembrane transporters
SLC transporter disorders
Protein-Protein Interactions (88)
1 – 10 of 88
AHCYL1
Tchem
Family: Enzyme
Novelty: 0.02176432
Score: 0.958
Data Source: STRINGDB
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
Score: 0.89
Data Source: STRINGDB
CA4
Tclin
Family: Enzyme
Novelty: 0.0004916
Score: 0.824
Data Source: STRINGDB
CA2
Tclin
Family: Enzyme
Novelty: 0.00040118
Score: 0.8
Data Source: STRINGDB
SLC26A4
Tbio
Family: Transporter
Novelty: 0.00162006
Score: 0.779
Data Source: STRINGDB
SLC26A6
Tbio
Family: IC
Novelty: 0.00922143
Score: 0.778
Data Source: STRINGDB
SLC9A3
Tclin
Family: Transporter
Novelty: 0.00146466
Score: 0.773
Data Source: STRINGDB
SLC9A1
Tchem
Family: Transporter
Novelty: 0.00096678
Score: 0.752
Data Source: STRINGDB
SLC12A2
Tclin
Family: Transporter
Novelty: 0.0012043
Score: 0.737
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.734
Data Source: STRINGDB
Publication Statistics
PubMed Score  315.82

PubMed score by year
PubTator Score  115.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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