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Tbio
NUMBL
Numb-like protein

Protein Classes
Protein Summary
Description
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252891
  • ENSP00000252891
  • ENSG00000105245

Symbol
  • NBL
  • CAG3A
  • CTG3a
  • NUMBR
  • NUMB-R
  • TNRC23
  • NUMBLIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
histone modification site profile
0.78
transcription factor
0.7
cell type or tissue
0.62
kinase perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.73   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.73   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
2
2
92.7
melanoma-derived growth regulatory protein measurement
1
2
2
79.5
hematocrit
2
2
2
68.5
2
2
0
1.5
66.6
appendicular lean mass
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
FEV/FEC ratio
2
92.7
melanoma-derived growth regulatory protein measurement
2
79.5
hematocrit
2
68.5
0
1.5
66.6
appendicular lean mass
1
57.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NUMB like, endocytic adaptor protein
VGNC:10250
468884
Macaque
NUMB like, endocytic adaptor protein
703485
Mouse
MGI:894702
18223
Rat
RGD:1307579
292732
Dog
NUMB like, endocytic adaptor protein
VGNC:44043
612491
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NUMB like, endocytic adaptor protein
Macaque
NUMB like, endocytic adaptor protein
Mouse
Rat
Dog
NUMB like, endocytic adaptor protein
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6R0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Notch signaling pathway
Name
Explore in Pharos
Explore in Source
Notch signaling pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (83)
1 – 10 of 83
NUMB
Tbio
Novelty:  0.00211228
p_int:  0.999999746
p_ni:  1e-9
p_wrong:  2.53e-7
Score:  0.81
Data Source:  BioPlex,STRINGDB
SLC1A1
Tchem
Family:  Transporter
Novelty:  0.00218479
p_int:  0.999998807
p_ni:  0.000001157
p_wrong:  3.6e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.995536991
p_ni:  0.000009219
p_wrong:  0.00445379
Data Source:  BioPlex
UNC5CL
Tbio
Novelty:  0.11511991
p_int:  0.978080304
p_ni:  0.000001337
p_wrong:  0.021918359
Score:  0.206
Data Source:  BioPlex,STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.961
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.902
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.898
Data Source:  STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
Score:  0.87
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.87
Data Source:  STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
Score:  0.862
Data Source:  STRINGDB
Publication Statistics
PubMed Score  73.73

PubMed score by year
PubTator Score  21.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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