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Tbio
TNFRSF11A
Tumor necrosis factor receptor superfamily member 11A

Protein Summary
Description
Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells. The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269485
  • ENSP00000269485
  • ENSG00000141655
  • ENST00000586569
  • ENSP00000465500
  • ENST00000616710
  • ENSP00000479567
  • ENST00000617039
  • ENSP00000482466

Symbol
  • RANK
  • FEO
  • OFE
  • ODFR
  • OSTS
  • PDB2
  • RANK
  • CD265
  • OPTB7
  • TRANCER
  • LOH18CR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
biological term
0.92
virus perturbation
0.88
disease
0.75
phenotype
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.06   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 701   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.06   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 701   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
2
6
95.8
2
2
0
1.5
93.6
bone density
5
2
7
90.4
3
3
0
1
70.4
3
1
2
1
68.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
95.8
0
1.5
93.6
bone density
7
90.4
0
1
70.4
2
1
68.3
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 11a
VGNC:5213
468560
Mouse
MGI:1314891
21934
Rat
RGD:1563614
498206
Dog
TNF receptor superfamily member 11a
VGNC:47654
483957
Horse
TNF receptor superfamily member 11a
VGNC:50982
100056617
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF receptor superfamily member 11a
Mouse
Rat
Dog
TNF receptor superfamily member 11a
Horse
TNF receptor superfamily member 11a
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6Q6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Reactome
TNFR2 non-canonical NF-kB pathway
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
TNFR2 non-canonical NF-kB pathway
Gene Ontology Terms (33)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (129)
1 – 10 of 129
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.998
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.982
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.00983658
Score: 0.953
Data Source: Reactome,STRINGDB
TRAF3
Tbio
Novelty: 0.0022525
Score: 0.947
Data Source: Reactome,STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.947
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.945
Data Source: STRINGDB
LTB
Tbio
Novelty: 0.00525424
Score: 0.943
Data Source: STRINGDB
TNFSF14
Tbio
Novelty: 0.01370893
Score: 0.937
Data Source: STRINGDB
MAP3K14
Tchem
Family: Kinase
Novelty: 0.0350173
Score: 0.927
Data Source: Reactome,STRINGDB
CD40LG
Tbio
Novelty: 0.00032058
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  121.06

PubMed score by year
PubTator Score  234.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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