You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STON1
Stonin-1

Protein Summary
Description
May be involved in the endocytic machinery. Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404752
  • ENSP00000385273
  • ENSG00000243244
  • ENST00000406226
  • ENSP00000384615
  • ENST00000649748
  • ENSP00000497745

Symbol
  • SALF
  • SBLF
  • STN1
  • SALF
  • SBLF
  • STN1
  • STNB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.61
phenotype
0.6
cell line
0.57
histone modification site profile
0.57
transcription factor
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 85   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (149)
SYT1
Tbio
Novelty:  0.00176103
Score:  0.959
Data Source:  STRINGDB
SYT2
Tbio
Novelty:  0.00754735
Score:  0.953
Data Source:  STRINGDB
EPS15
Tchem
Novelty:  0.00451447
Score:  0.946
Data Source:  STRINGDB
ITSN1
Tbio
Novelty:  0.01327346
Score:  0.939
Data Source:  STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
Score:  0.937
Data Source:  STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
Score:  0.934
Data Source:  STRINGDB
SNAP91
Tbio
Novelty:  0.0083886
Score:  0.934
Data Source:  STRINGDB
SYNJ1
Tchem
Novelty:  0.01030746
Score:  0.934
Data Source:  STRINGDB
AP2M1
Tbio
Novelty:  0.00769368
Score:  0.932
Data Source:  STRINGDB
EPN2
Tbio
Novelty:  0.06405828
Score:  0.93
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
2
2
55.8
reticulocyte count
2
2
2
50.6
serum non-albumin protein measurement
1
1
1
36.9
sex hormone-binding globulin measurement
1
1
1
33.1
1
1
0
1.1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
2
55.8
reticulocyte count
2
50.6
serum non-albumin protein measurement
1
36.9
sex hormone-binding globulin measurement
1
33.1
0
1.1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs
No orthologs found
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 14.04
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title