Protein Summary
May be involved in the endocytic machinery. Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]
- ENST00000404752
- ENSP00000385273
- ENSG00000243244
- ENST00000406226
- ENSP00000384615
- ENST00000649748
- ENSP00000497745
- SALF
- SBLF
- STN1
- SALF
- SBLF
- STN1
- STNB1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
trait | 0.61 | ||
phenotype | 0.6 | ||
cell line | 0.57 | ||
histone modification site profile | 0.57 | ||
transcription factor | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.73 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 85 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.73 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 85 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (149)
Nearest Tclin Targets
Pathways (4)
Reactome (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cargo recognition for clathrin-mediated endocytosis | ||||
Reactome | Clathrin-mediated endocytosis | ||||
Reactome | Membrane Trafficking | ||||
Reactome | Vesicle-mediated transport | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cargo recognition for clathrin-mediated endocytosis | ||||
Clathrin-mediated endocytosis | ||||
Membrane Trafficking | ||||
Vesicle-mediated transport | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Components (2)
Processes (2)
Disease Associations ()
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 2 | 2 | 55.8 | |||||
reticulocyte count | 2 | 2 | 2 | 50.6 | |||||
serum non-albumin protein measurement | 1 | 1 | 1 | 36.9 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 33.1 | |||||
1 | 1 | 0 | 1.1 | 24.5 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 2 | 55.8 | |||||
reticulocyte count | 2 | 50.6 | |||||
serum non-albumin protein measurement | 1 | 36.9 | |||||
sex hormone-binding globulin measurement | 1 | 33.1 | |||||
0 | 1.1 | 24.5 | |||||
Find similar targets by:
IDG Resources
Orthologs
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 14.04
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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