Tbio STON1 Stonin-1

Protein Summary

Description

May be involved in the endocytic machinery. Endocytosis of cell surface proteins is mediated by a complex molecular machinery that assembles on the inner surface of the plasma membrane. This gene encodes one of two human homologs of the Drosophila melanogaster stoned B protein. This protein is related to components of the endocytic machinery and exhibits a modular structure consisting of an N-terminal proline-rich domain, a central region of homology specific to the human stoned B-like proteins, and a C-terminal region homologous to the mu subunits of adaptor protein (AP) complexes. Read-through transcription of this gene into the neighboring downstream gene, which encodes TFIIA-alpha/beta-like factor, generates a transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• Q9Y6Q2
• A0A0A6YYH4
• A8MXJ1
• B5MCF5
• B7ZL16
• Q96JE3
• Q9BYX3

Gene Name

• STON1

Ensembl ID

• ENST00000404752
• ENSP00000385273
• ENSG00000243244
• ENST00000406226
• ENSP00000384615
• ENST00000649748
• ENSP00000497745

Symbol

• SALF
• SBLF
• STN1
• SALF
• SBLF
• STN1
• STNB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
trait	0.61
phenotype	0.6
cell line	0.57
histone modification site profile	0.57
transcription factor	0.56

Protein Classes

PANTHER Classes

Protein / Receptor / Stonin-1

Protein / Extracellular Matrix Protein / Extracellular Matrix Glycoprotein / Stonin-1

DTO Classes

Protein / Extracellular Structure / Extracellular Matrix Glycoprotein / Stonin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.63   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 85   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.63   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 85   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0