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Tbio
CAPN6
Calpain-6

Protein Summary
Description
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The protein encoded by this gene is highly expressed in the placenta. Its C-terminal region lacks any homology to the calmodulin-like domain of other calpains. The protein lacks critical active site residues ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324068
  • ENSP00000317214
  • ENSG00000077274

Symbol
  • CALPM
  • CANPX
  • CANPX
  • CAPNX
  • CalpM
  • DJ914P14.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
microRNA
0.84
disease perturbation
0.62
gene perturbation
0.61
PubMedID
0.58


Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.55   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calpain 6
VGNC:1403
465810
Macaque
calpain 6
706434
Mouse
MGI:1100850
12338
Rat
RGD:70960
83685
Dog
calpain 6
VGNC:38706
492068
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calpain 6
Macaque
calpain 6
Mouse
Rat
Dog
calpain 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6Q1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (110)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (71)
1 – 10 of 71
SYNE2
Tbio
Novelty:  0.01368736
p_int:  0.999997829
p_ni:  0.000002171
Score:  0.241
Data Source:  BioPlex,STRINGDB
BAZ1A
Tbio
Family:  Epigenetic
Novelty:  0.01833837
p_int:  0.999976067
p_ni:  0.000023932
Score:  0.323
Data Source:  BioPlex,STRINGDB
CEP162
Tdark
Novelty:  0.03171049
p_int:  0.999870748
p_ni:  0.000129252
Score:  0.199
Data Source:  BioPlex,STRINGDB
SUN1
Tbio
Novelty:  0.00931817
p_int:  0.999520965
p_ni:  0.000479035
Score:  0.177
Data Source:  BioPlex,STRINGDB
LRFN4
Tbio
Novelty:  0.12511571
p_int:  0.998968648
p_ni:  0.001031351
Data Source:  BioPlex
UBA6
Tchem
Novelty:  0.05213412
p_int:  0.974302057
p_ni:  0.025694947
p_wrong:  0.000002996
Score:  0.169
Data Source:  BioPlex,STRINGDB
CHRAC1
Tbio
Novelty:  0.17492099
p_int:  0.973881747
p_ni:  0.025253461
p_wrong:  0.000864793
Score:  0.207
Data Source:  BioPlex,STRINGDB
FLNA
Tbio
Novelty:  0.00156479
p_int:  0.943511427
p_ni:  0.056488573
Score:  0.329
Data Source:  BioPlex,STRINGDB
HECTD1
Tbio
Family:  Enzyme
Novelty:  0.28016112
p_int:  0.90235269
p_ni:  0.09764731
Score:  0.214
Data Source:  BioPlex,STRINGDB
BICD2
Tbio
Novelty:  0.01725046
p_int:  0.897254595
p_ni:  0.102593441
p_wrong:  0.000151964
Score:  0.177
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  27.55

PubMed score by year
PubTator Score  11.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer