Protein Summary
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity). May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1 (PubMed:23274085). May have an alkylhydroperoxide reductase activity born by the N-terminal domain of the protein (By similarity). Was originally reported to contribute to oxidative stress resistance by reducing PRDX1 (PubMed:15105503). However, this could not be confirmed (By similarity). This gene encodes a member of the sestr ...more
- ENST00000302071
- ENSP00000306734
- ENSG00000080546
- ENST00000356644
- ENSP00000349061
- ENST00000436639
- ENSP00000393762
- PA26
- SEST1
- PA26
- SEST1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.97 | ||
kinase perturbation | 0.88 | ||
disease perturbation | 0.83 | ||
transcription factor binding site profile | 0.82 | ||
gene perturbation | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.43 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 241 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.43 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 241 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (78)
Nearest Tclin Targets
Pathways (12)
Reactome (5)
KEGG (2)
PathwayCommons (1)
WikiPathways (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Gene expression (Transcription) | ||||
Reactome | Generic Transcription Pathway | ||||
Reactome | RNA Polymerase II Transcription | ||||
Reactome | TP53 Regulates Metabolic Genes | ||||
Reactome | Transcriptional Regulation by TP53 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Gene expression (Transcription) | ||||
Generic Transcription Pathway | ||||
RNA Polymerase II Transcription | ||||
TP53 Regulates Metabolic Genes | ||||
Transcriptional Regulation by TP53 | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (3)
Components (4)
Processes (10)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 1 | 1 | 83.8 | |||||
forced expiratory volume | 1 | 1 | 1 | 77.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 74.3 | |||||
birth weight | 3 | 3 | 3 | 66.2 | |||||
2 | 1 | 0 | 1.1 | 64 | |||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
FEV/FEC ratio | 1 | 83.8 | |||||
forced expiratory volume | 1 | 77.7 | |||||
high density lipoprotein cholesterol measurement | 1 | 74.3 | |||||
birth weight | 3 | 66.2 | |||||
0 | 1.1 | 64 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | sestrin 1 | VGNC:3701 | 462922 | |||||
Macaque | sestrin 1 | 700232 | ||||||
Mouse | MGI:2155278 | 140742 | ||||||
Rat | RGD:1307517 | 294518 | ||||||
Dog | sestrin 1 | VGNC:46047 | 481956 | |||||
Publication Statistics
PubMed Score 80.43
PubMed score by year
PubTator Score 29.82
PubTator score by year
Related Publications
Text Mined References (22)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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