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Tbio
ROBO1
Roundabout homolog 1

Protein Summary
Description
Receptor for SLIT1 and SLIT2 that mediates cellular responses to molecular guidance cues in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development (PubMed:10102268, PubMed:24560577). Interaction with the intracellular domain of FLRT3 mediates axon attraction towards cells expressing NTN1 (PubMed:24560577). In axon growth cones, the silencing of the attractive effect of NTN1 by SLIT2 may require the formation of a ROBO1-DCC complex (By similarity). Plays a role in the regulation of cell migration via its interaction with MYO9B; inhibits MYO9B-mediated stimulation of RHOA GTPase activity, and thereby leads to increased levels of active, GTP-bound RHOA (PubMed:26529257). May be required for lung development (By similarity). Bilateral symmetric nervous systems have special midline structures that establish a partition between the two mirror image halves. Some axons project toward and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000464233
  • ENSP00000420321
  • ENSG00000169855
  • ENST00000467549
  • ENSP00000417992
  • ENST00000495273
  • ENSP00000420637

Symbol
  • DUTT1
  • SAX3
  • DUTT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.91
ligand (protein) perturbation
0.83
transcription factor perturbation
0.8
virus perturbation
0.79
cell type or tissue
0.75


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.6   (req: < 5)
Gene RIFs: 85   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 220.6   (req: >= 5)
Gene RIFs: 85   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
1
1
44.2
mathematical ability
3
2
3
40.4
Hemifacial microsomia
1
1
0
5.2
39.6
body mass index
1
1
1
38.8
self reported educational attainment
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
1
44.2
mathematical ability
3
40.4
Hemifacial microsomia
0
5.2
39.6
body mass index
1
38.8
self reported educational attainment
1
21.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
roundabout guidance receptor 1
VGNC:2539
460518
Mouse
MGI:1274781
19876
Rat
RGD:61941
58946
Dog
roundabout guidance receptor 1
VGNC:45684
487690
Horse
roundabout guidance receptor 1
VGNC:22492
100069075
Species
Name
OMA
EggNOG
Inparanoid
Chimp
roundabout guidance receptor 1
Mouse
Rat
Dog
roundabout guidance receptor 1
Horse
roundabout guidance receptor 1
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6N7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Activation of RAC1 (R-HSA-428540)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of RAC1
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
Netrin-1 signaling
Name
Explore in Pharos
Explore in Source
Activation of RAC1
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
Netrin-1 signaling
Gene Ontology Terms (35)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (143)
1 – 10 of 143
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999999856
p_ni:  1.42e-7
p_wrong:  1e-9
Data Source:  BioPlex
GDPD5
Tbio
Family:  Enzyme
Novelty:  0.05871733
p_int:  0.999995668
p_ni:  0.000004278
p_wrong:  5.5e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
CMKLR1
Tchem
Family:  GPCR
Novelty:  0.00893083
p_int:  0.999981953
p_ni:  0.000014718
p_wrong:  0.000003329
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.999972804
p_ni:  0.000026066
p_wrong:  0.000001129
Data Source:  BioPlex
PRSS21
Tbio
Family:  Enzyme
Novelty:  0.0110251
p_int:  0.917954163
p_ni:  0.001463669
p_wrong:  0.080582168
Data Source:  BioPlex
SH2D1B
Tbio
Novelty:  0.01535146
p_int:  0.91155529
p_ni:  0.001585281
p_wrong:  0.086859429
Data Source:  BioPlex
SLIT2
Tbio
Novelty:  0.00710401
Score:  0.999
Data Source:  Reactome,STRINGDB
SLIT3
Tbio
Novelty:  0.00465012
Score:  0.998
Data Source:  Reactome,STRINGDB
SLIT1
Tbio
Novelty:  0.01255624
Score:  0.996
Data Source:  Reactome,STRINGDB
SRGAP1
Tbio
Family:  Enzyme
Novelty:  0.07072132
Score:  0.99
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  220.60

PubMed score by year
PubTator Score  137.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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