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Tbio
COX11
Cytochrome c oxidase assembly protein COX11, mitochondrial

Protein Summary
Description
Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I. Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be a heme A biosynthetic enzyme involved in COX formation, according to the yeast mutant studies. However, the studies in Rhodobacter sphaeroides suggest that this gene is not required for heme A biosynthesis, but required for stable formation of the Cu(B) and magnesium centers of C ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299335
  • ENSP00000299335
  • ENSG00000166260
  • ENST00000572558
  • ENSP00000459302
  • ENST00000576370
  • ENSP00000459901
  • ENST00000639671
  • ENSP00000492488

Symbol
  • COX11P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
molecular function
0.79
transcription factor binding site profile
0.72
microRNA
0.68
tissue sample
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 123   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.6   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 123   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (103)
ERCC3
Tbio
Family:  Enzyme
Novelty:  0.00978601
p_int:  0.95803849
p_ni:  0.04196151
Score:  0.199
Data Source:  BioPlex,STRINGDB
KLK5
Tchem
Family:  Enzyme
Novelty:  0.00835407
p_int:  0.830367966
p_ni:  0.169632034
Score:  0.211
Data Source:  BioPlex,STRINGDB
CYCS
Tchem
Novelty:  0.00014004
Score:  0.977
Data Source:  STRINGDB
SCO1
Tbio
Novelty:  0.01012315
Score:  0.959
Data Source:  STRINGDB
COX17
Tbio
Family:  Enzyme
Novelty:  0.01025112
Score:  0.94
Data Source:  STRINGDB
COX19
Tbio
Family:  Enzyme
Novelty:  0.06540633
Score:  0.939
Data Source:  STRINGDB
COX15
Tbio
Family:  Enzyme
Novelty:  0.02252282
Score:  0.924
Data Source:  STRINGDB
CNNM4
Tbio
Novelty:  0.04199329
Score:  0.922
Data Source:  STRINGDB
SCO2
Tbio
Novelty:  0.00680753
Score:  0.907
Data Source:  STRINGDB
COX10
Tbio
Family:  Enzyme
Novelty:  0.0156235
Score:  0.904
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism
Reactome
RNA Polymerase II Transcription
Reactome
Respiratory electron transport
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism
RNA Polymerase II Transcription
Respiratory electron transport
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
1
1
63.4
4
1
0
1.1
58.4
mosaic loss of chromosome Y measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
1
63.4
0
1.1
58.4
mosaic loss of chromosome Y measurement
1
40.7
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
COX11, cytochrome c oxidase copper chaperone
VGNC:12146
748332
Macaque
COX11 homolog, cytochrome c oxidase assembly protein
641445
Mouse
MGI:1917052
69802
Dog
COX11 cytochrome c oxidase assembly homolog (yeast)
609555
Horse
COX11, cytochrome c oxidase copper chaperone
VGNC:51473
100056543
Species
Name
OMA
EggNOG
Inparanoid
Chimp
COX11, cytochrome c oxidase copper chaperone
Macaque
COX11 homolog, cytochrome c oxidase assembly protein
Mouse
Dog
COX11 cytochrome c oxidase assembly homolog (yeast)
Horse
COX11, cytochrome c oxidase copper chaperone
Publication Statistics
PubMed Score 37.60
PubMed score by year
PubTator Score 11.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title