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Tclin
NDUFB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. The protein encoded by this gene is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). Complex I is localized to the inner mitochondrial membrane and functions to dehydrogenate nicotinamide adenine dinucleotide and to shuttle electrons to coenzyme Q. Complex I deficiency is the most common defect found in oxidative phosphorylation disorders and results in a range of conditions, including lethal neonatal disease, hypertrophic cardiomyopathy, liver disease, and adult-onset neurodegenerative disorders. Pseudogenes of this gene are found on chromosomes five, seven and eight. Alternative splicing results in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276689
  • ENSP00000276689
  • ENSG00000147684

Symbol
  • LYRM3
  • UQOR22
  • B22
  • LYRM3
  • CI-B22
  • UQOR22
  • MC1DN24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.99
disease perturbation
0.96
histone modification site profile
0.89
transcription factor perturbation
0.88
cellular component
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.87   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 287   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 138.87   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 287   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
5.9
25.8
traffic air pollution measurement
1
1
0
5.9
25.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
5.9
25.8
traffic air pollution measurement
0
5.9
25.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B9
VGNC:6571
464380
Macaque
NADH:ubiquinone oxidoreductase subunit B9
711387
Mouse
MGI:1913468
66218
Rat
RGD:1307114
299954
Dog
NADH:ubiquinone oxidoreductase subunit B9
VGNC:43706
475094
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit B9
Macaque
NADH:ubiquinone oxidoreductase subunit B9
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase subunit B9
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6M9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (118)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (215)
1 – 10 of 215
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999999601
p_ni: 3.14e-7
p_wrong: 8.5e-8
Score: 0.99
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999995335
p_ni: 0.000003323
p_wrong: 0.000001342
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.99999167
p_ni: 0.00000833
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.99992386
p_ni: 0.00007614
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.99967634
p_ni: 0.000323613
p_wrong: 4.7e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB5
Tclin
Family: Enzyme
Novelty: 0.0257403
p_int: 0.999618365
p_ni: 0.000380901
p_wrong: 7.33e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.999590904
p_ni: 0.000409096
p_wrong: 1e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
RHPN1
Tbio
Novelty: 0.05722992
p_int: 0.998832072
p_ni: 0.001167928
Data Source: BioPlex
NDUFA9
Tclin
Family: Enzyme
Novelty: 0.00637307
p_int: 0.998416064
p_ni: 0.001560374
p_wrong: 0.000023563
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.998336167
p_ni: 0.001663476
p_wrong: 3.57e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  138.87

PubMed score by year
PubTator Score  129.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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