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Tbio
SLC4A7
Sodium bicarbonate cotransporter 3

Protein Summary
Description
Electroneutral sodium- and bicarbonate-dependent cotransporter with a Na(+):HCO3(-) 1:1 stoichiometry. Regulates intracellular pH and may play a role in bicarbonate salvage in secretory epithelia. May also have an associated sodium channel activity. This locus encodes a sodium bicarbonate cotransporter. The encoded transmembrane protein appears to transport sodium and bicarbonate ions in a 1:1 ratio, and is thus considered an electroneutral cotransporter. The encoded protein likely plays a critical role in regulation of intracellular pH involved in visual and auditory sensory transmission. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295736
  • ENSP00000295736
  • ENSG00000033867
  • ENST00000428386
  • ENSP00000416368
  • ENST00000437179
  • ENSP00000394252
  • ENST00000437266
  • ENSP00000409418
  • ENST00000438530
  • ENSP00000407304
  • ENST00000440156
  • ENSP00000414797
  • ENST00000446700
  • ENSP00000406605
  • ENST00000454389
  • ENSP00000390394
  • ENST00000455077
  • ENSP00000407382
  • ENST00000457377
  • ENSP00000408323

Symbol
  • BT
  • NBC2
  • NBC2B
  • NBC3
  • NBCn1
  • SBC2
  • SLC4A6
  • NBC2
  • NBC3
  • SBC2
  • NBCN1
  • SLC4A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.98
drug perturbation
0.87
molecular function
0.81
microRNA
0.78
gene perturbation
0.75


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.63   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.63   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1
0
1.1
95.8
diastolic blood pressure
1
1
2
53.1
platelet crit
1
1
1
36
platelet count
1
1
1
32.2
Beta blocking agent use measurement
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
95.8
diastolic blood pressure
2
53.1
platelet crit
1
36
platelet count
1
32.2
Beta blocking agent use measurement
1
20.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 7
VGNC:8010
460236
Mouse
MGI:2443878
218756
Rat
RGD:621208
117955
Dog
solute carrier family 4 member 7
VGNC:46436
485637
Horse
solute carrier family 4 member 7
VGNC:23236
100051260
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 4 member 7
Mouse
Rat
Dog
solute carrier family 4 member 7
Horse
solute carrier family 4 member 7
Pathways (4)
Bicarbonate transporters (R-HSA-425381)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bicarbonate transporters
Reactome
SLC-mediated transmembrane transport
Reactome
Transport of inorganic cations/anions and amino acids/oligopeptides
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Bicarbonate transporters
SLC-mediated transmembrane transport
Transport of inorganic cations/anions and amino acids/oligopeptides
Transport of small molecules
Protein-Protein Interactions (91)
1 – 10 of 91
MSMB
Tbio
Novelty: 0.00241546
p_int: 0.999991886
p_ni: 0.000008114
Data Source: BioPlex
LGALS8
Tchem
Novelty: 0.00623836
p_int: 0.999986049
p_ni: 0.00001395
p_wrong: 1e-9
Data Source: BioPlex
GDE1
Tbio
Family: Enzyme
Novelty: 0.05854843
p_int: 0.99997501
p_ni: 0.000024955
p_wrong: 3.5e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
CCL26
Tbio
Novelty: 0.00556498
p_int: 0.999967859
p_ni: 0.000032141
Data Source: BioPlex
EGFL8
Tbio
Novelty: 0.01309625
p_int: 0.999879093
p_ni: 0.000120905
p_wrong: 2e-9
Score: 0.204
Data Source: BioPlex,STRINGDB
LGALS9C
Tdark
Novelty: 0.29969898
p_int: 0.999866192
p_ni: 0.000133807
p_wrong: 1e-9
Score: 0.586
Data Source: BioPlex,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.11166611
p_int: 0.999862047
p_ni: 0.0001379
p_wrong: 5.3e-8
Data Source: BioPlex
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.99985869
p_ni: 0.00014131
Score: 0.243
Data Source: BioPlex,STRINGDB
PDZK1P1
Tdark
p_int: 0.999845259
p_ni: 0.000154741
Data Source: BioPlex
RASD2
Tbio
Family: Enzyme
Novelty: 0.00490468
p_int: 0.999782151
p_ni: 0.000217846
p_wrong: 3e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  94.63

PubMed score by year
PubTator Score  60.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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