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Tbio
CSNK1G3
Casein kinase I isoform gamma-3

Protein Summary
Description
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345990
  • ENSP00000334735
  • ENSG00000151292
  • ENST00000360683
  • ENSP00000353904
  • ENST00000361991
  • ENSP00000354942
  • ENST00000510842
  • ENSP00000423838
  • ENST00000511130
  • ENSP00000421385
  • ENST00000512718
  • ENSP00000421998
  • ENST00000521364
  • ENSP00000429412

Symbol
  • CSNK1G3L
  • CKI-gamma 3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.91
molecular function
0.9
transcription factor binding site profile
0.74
protein domain
0.73


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.86   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.86   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
4
94.5
low density lipoprotein cholesterol measurement
6
4
7
91.8
red blood cell distribution width
2
1
2
57.7
apolipoprotein B measurement
1
1
1
57.5
total cholesterol measurement
2
1
2
30.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
94.5
low density lipoprotein cholesterol measurement
7
91.8
red blood cell distribution width
2
57.7
apolipoprotein B measurement
1
57.5
total cholesterol measurement
2
30.1
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (69)
1 – 10 of 69
CSNK1G2
Tchem
Family: Kinase
Novelty: 0.17930147
p_int: 1
Score: 0.535
Data Source: BioPlex,STRINGDB
CSNK1G1
Tchem
Family: Kinase
Novelty: 0.10919141
p_int: 0.999999999
p_ni: 1e-9
Score: 0.557
Data Source: BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.999371892
p_ni: 0.000624073
p_wrong: 0.000004035
Data Source: BioPlex
SDC1
Tbio
Novelty: 0.00044792
p_int: 0.997757967
p_ni: 0.002242033
Data Source: BioPlex
EIF1AD
Tdark
Novelty: 0.23915521
p_int: 0.997062663
p_ni: 0.002937156
p_wrong: 1.82e-7
Data Source: BioPlex
S1PR2
Tchem
Family: GPCR
Novelty: 0.00372765
p_int: 0.974912519
p_ni: 0.02508737
p_wrong: 1.11e-7
Data Source: BioPlex
GPR156
Tdark
Family: GPCR
Novelty: 0.39183023
p_int: 0.971566113
p_ni: 0.028433594
p_wrong: 2.93e-7
Data Source: BioPlex
CYP2S1
Tbio
Novelty: 0.02967417
p_int: 0.971135464
p_ni: 0.028864535
p_wrong: 1e-9
Data Source: BioPlex
GJB7
Tbio
Novelty: 0.12555147
p_int: 0.964345686
p_ni: 0.035654137
p_wrong: 1.77e-7
Data Source: BioPlex
RNF11
Tbio
Novelty: 0.04766714
p_int: 0.956722413
p_ni: 0.043277545
p_wrong: 4.1e-8
Score: 0.212
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.86

PubMed score by year
PubTator Score  2.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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