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Tchem
CSNK1G3
Casein kinase I isoform gamma-3

Protein Summary
Description
Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345990
  • ENSP00000334735
  • ENSG00000151292
  • ENST00000360683
  • ENSP00000353904
  • ENST00000361991
  • ENSP00000354942
  • ENST00000510842
  • ENSP00000423838
  • ENST00000511130
  • ENSP00000421385
  • ENST00000512718
  • ENSP00000421998
  • ENST00000521364
  • ENSP00000429412

Symbol
  • CSNK1G3L
  • CKI-gamma 3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
transcription factor perturbation
0.91
molecular function
0.9
transcription factor binding site profile
0.74
protein domain
0.73


Related Tools
Dark Kinase Knowledgebase
Thumbnail image for Dark Kinase Knowledgebase
The Dark Kinase Knowledgebase is an an online compendium of knowledge and experimental results of understudied kinases.
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 157   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.93   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
5
90.5
low density lipoprotein cholesterol measurement
6
4
7
89
apolipoprotein B measurement
1
1
1
73.9
appendicular lean mass
1
2
2
72.2
sex hormone-binding globulin measurement
2
2
2
58.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
90.5
low density lipoprotein cholesterol measurement
7
89
apolipoprotein B measurement
1
73.9
appendicular lean mass
2
72.2
sex hormone-binding globulin measurement
2
58.2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 gamma 3
VGNC:11898
462027
Macaque
casein kinase 1 gamma 3
701702
Mouse
MGI:1917675
70425
Rat
RGD:621408
64823
Dog
casein kinase 1 gamma 3
VGNC:39669
481481
Species
Name
OMA
EggNOG
Inparanoid
Chimp
casein kinase 1 gamma 3
Macaque
casein kinase 1 gamma 3
Mouse
Rat
Dog
casein kinase 1 gamma 3
Protein Structure (10 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6M4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (16)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Hedgehog signaling pathway
Name
Explore in Pharos
Explore in Source
Hedgehog signaling pathway
Gene Ontology Terms (12)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (69)
1 – 10 of 69
CSNK1G2
Tchem
Family:  Kinase
Novelty:  0.17930147
p_int:  1
Score:  0.535
Data Source:  BioPlex,STRINGDB
CSNK1G1
Tchem
Family:  Kinase
Novelty:  0.10919141
p_int:  0.999999999
p_ni:  1e-9
Score:  0.557
Data Source:  BioPlex,STRINGDB
ANKRD13D
Tdark
Novelty:  2.14380936
p_int:  0.999371892
p_ni:  0.000624073
p_wrong:  0.000004035
Data Source:  BioPlex
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.997757967
p_ni:  0.002242033
Data Source:  BioPlex
EIF1AD
Tdark
Novelty:  0.23915521
p_int:  0.997062663
p_ni:  0.002937156
p_wrong:  1.82e-7
Data Source:  BioPlex
S1PR2
Tchem
Family:  GPCR
Novelty:  0.00372765
p_int:  0.974912519
p_ni:  0.02508737
p_wrong:  1.11e-7
Data Source:  BioPlex
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
p_int:  0.971566113
p_ni:  0.028433594
p_wrong:  2.93e-7
Data Source:  BioPlex
CYP2S1
Tbio
Novelty:  0.02967417
p_int:  0.971135464
p_ni:  0.028864535
p_wrong:  1e-9
Data Source:  BioPlex
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.964345686
p_ni:  0.035654137
p_wrong:  1.77e-7
Data Source:  BioPlex
RNF11
Tbio
Novelty:  0.04766714
p_int:  0.956722413
p_ni:  0.043277545
p_wrong:  4.1e-8
Score:  0.212
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.93

PubMed score by year
PubTator Score  2.33

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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