Tchem CSNK1G3 Casein kinase I isoform gamma-3

Protein Summary

Description

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Regulates fast synaptic transmission mediated by glutamate (By similarity). This gene encodes a member of a family of serine/threonine protein kinases that phosphorylate caseins and other acidic proteins. A related protein in the African clawed frog participates in the transmission of Wnt/beta-catenin signaling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q9Y6M4
• A8K040
• B4DSH2
• B7Z9Q4
• E7EVD0
• Q86WZ7
• Q9Y6M3
• CKI-gamma 3

Gene Name

• CSNK1G3

Ensembl ID

• ENST00000345990
• ENSP00000334735
• ENSG00000151292
• ENST00000360683
• ENSP00000353904
• ENST00000361991
• ENSP00000354942
• ENST00000510842
• ENSP00000423838
• ENST00000511130
• ENSP00000421385
• ENST00000512718
• ENSP00000421998
• ENST00000521364
• ENSP00000429412

Symbol

• CSNK1G3L
• CKI-gamma 3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
transcription factor perturbation	0.91
molecular function	0.9
transcription factor binding site profile	0.74
protein domain	0.73

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Casein Kinase I Isoform Gamma-3

DTO Classes

Protein / Kinase / Protein Kinase / Ck1 Group / Ck1 Family / Casein Kinase I Isoform Gamma-3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.46   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0