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Tbio
PRSS21
Testisin

Protein Summary
Description
Could regulate proteolytic events associated with testicular germ cell maturation. This gene encodes a cell-surface anchored serine protease, which is a member of the trypsin family of serine proteases. The encoded protein is predicted to be active on peptide linkages involving the carboxyl group of lysine or arginine. The encoded protein localizes to the cytoplasm and the plasma membrane of premeiotic testicular germ cells and may be involved in progression of testicular tumors of germ cell origin. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005995
  • ENSP00000005995
  • ENSG00000007038
  • ENST00000450020
  • ENSP00000407741
  • ENST00000634351
  • ENSP00000489315
  • ENSG00000282838
  • ENST00000634454
  • ENSP00000489081

Symbol
  • ESP1
  • TEST1
  • ESP1
  • ESP-1
  • TEST1
  • TESTISIN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
0.99
gene perturbation
0.7
protein domain
0.58
tissue sample
0.54
tissue
0.52


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 55   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 55   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (14)
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
3
3
93.4
eosinophil count
3
3
3
93.4
eosinophil percentage of leukocytes
2
2
2
87.5
eosinophil percentage of leukocytes
2
2
2
87.5
body height
1
1
1
65.5
Items per page:
1 – 5 of 14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
3
93.4
eosinophil count
3
93.4
eosinophil percentage of leukocytes
2
87.5
eosinophil percentage of leukocytes
2
87.5
body height
1
65.5
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serine protease 21
VGNC:4832
453844
Macaque
protease, serine 21
699296
Mouse
MGI:1916698
57256
Rat
RGD:727870
353251
Pig
testisin-like
100737333
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serine protease 21
Macaque
protease, serine 21
Mouse
Rat
Pig
testisin-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6M0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational modification: synthesis of GPI-anchored proteins
Post-translational protein modification
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (97)
1 – 10 of 97
BST1
Tbio
Family:  Enzyme
Novelty:  0.01329061
p_int:  0.999795291
p_ni:  0.000009062
p_wrong:  0.000195647
Score:  0.9
Data Source:  BioPlex,STRINGDB
SMOC1
Tbio
Novelty:  0.03819681
p_int:  0.994388337
p_ni:  0.005528486
p_wrong:  0.000083178
Data Source:  BioPlex
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.982474348
p_ni:  0.017523821
p_wrong:  0.000001831
Data Source:  BioPlex
SPCS1
Tbio
Family:  Enzyme
Novelty:  0.0731223
p_int:  0.974176659
p_ni:  0.009137352
p_wrong:  0.01668599
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.96852727
p_ni:  0.03147273
Data Source:  BioPlex
FKBP14
Tbio
Family:  Enzyme
Novelty:  0.02742616
p_int:  0.955359667
p_ni:  0.044639181
p_wrong:  0.000001152
Data Source:  BioPlex
ROBO1
Tbio
Novelty:  0.00494884
p_int:  0.917954163
p_ni:  0.001463669
p_wrong:  0.080582168
Data Source:  BioPlex
ABHD17B
Tbio
Family:  Enzyme
Novelty:  0.64360453
p_int:  0.85323527
p_ni:  0.078096524
p_wrong:  0.068668206
Data Source:  BioPlex
CANX
Tbio
Novelty:  0.00087002
p_int:  0.841077017
p_ni:  0.158922983
Data Source:  BioPlex
FSTL1
Tbio
Novelty:  0.00557848
p_int:  0.835528861
p_ni:  0.154708532
p_wrong:  0.009762607
Data Source:  BioPlex
Publication Statistics
PubMed Score  91.32

PubMed score by year
PubTator Score  560.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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