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Tchem
TLL2
Tolloid-like protein 2

Protein Summary
Description
Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis. This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357947
  • ENSP00000350630
  • ENSG00000095587

Symbol
  • KIAA0932
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.75
histone modification site profile
0.72
kinase perturbation
0.66
transcription factor binding site profile
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 48   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 48   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
59
aging
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
59
aging
1
24.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tolloid like 2
VGNC:12511
450644
Mouse
MGI:1346044
24087
Rat
RGD:1559756
365460
Horse
tolloid like 2
VGNC:24134
100070823
Cow
tolloid like 2
VGNC:35896
504975
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tolloid like 2
Mouse
Rat
Horse
tolloid like 2
Cow
tolloid like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9Y6L7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Anchoring fibril formation (R-HSA-2214320)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring fibril formation
Reactome
Assembly of collagen fibrils and other multimeric structures
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Reactome
Crosslinking of collagen fibrils
Name
Explore in Pharos
Explore in Source
Anchoring fibril formation
Assembly of collagen fibrils and other multimeric structures
Collagen biosynthesis and modifying enzymes
Collagen formation
Crosslinking of collagen fibrils
Protein-Protein Interactions (46)
1 – 10 of 46
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999999985
p_wrong:  1.5e-8
Score:  0.21
Data Source:  BioPlex,STRINGDB
OS9
Tbio
Novelty:  0.01490339
p_int:  0.972080965
p_ni:  0.000260256
p_wrong:  0.027658779
Data Source:  BioPlex
CHRD
Tbio
Novelty:  0.00347659
Score:  0.923
Data Source:  STRINGDB
COL1A1
Tbio
Novelty:  0.00063584
Score:  0.915
Data Source:  STRINGDB
PCOLCE
Tbio
Family:  Enzyme
Novelty:  0.02012457
Score:  0.913
Data Source:  Reactome,STRINGDB
COL3A1
Tbio
Novelty:  0.00197327
Score:  0.911
Data Source:  STRINGDB
COL2A1
Tbio
Novelty:  0.0011102
Score:  0.911
Data Source:  STRINGDB
COL1A2
Tbio
Novelty:  0.00048334
Score:  0.911
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.911
Data Source:  STRINGDB
COL5A1
Tbio
Novelty:  0.00506815
Score:  0.911
Data Source:  STRINGDB
Publication Statistics
PubMed Score  17.17

PubMed score by year
PubTator Score  4.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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