SLCO1B1
Solute carrier organic anion transporter family member 1B1
Protein Summary
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
- ENST00000256958
- ENSP00000256958
- ENSG00000134538
- LST1
- OATP1B1
- OATP2
- OATPC
- SLC21A6
- LST1
- HBLRR
- LST-1
- OATP2
- OATPC
- OATP-C
- OATP1B1
- SLC21A6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
biological term | 0.9 | ||
chemical | 0.86 | ||
disease | 0.8 | ||
phenotype | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 845.62 (req: < 5)
Gene RIFs: 230 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 845.62 (req: >= 5)
Gene RIFs: 230 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 38
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 11
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (11)
Active Ligands (38)
Protein-Protein Interactions (93)
USO1
Novelty: 0.02066669
p_int: 0.999995224
p_ni: 0.000004776
Score: 0.169
Data Source: BioPlex,STRINGDB
VAMP3
Novelty: 0.00694332
p_int: 0.947607911
p_ni: 0.052391858
p_wrong: 2.31e-7
Data Source: BioPlex
MZT2B
Novelty: 0.69469786
p_int: 0.937981882
p_ni: 0.037408301
p_wrong: 0.024609817
Score: 0.183
Data Source: BioPlex,STRINGDB
SYNGR2
Novelty: 0.1089664
p_int: 0.932512915
p_ni: 0.06746861
p_wrong: 0.000018475
Score: 0.181
Data Source: BioPlex,STRINGDB
ORMDL2
Novelty: 0.37598406
p_int: 0.931906408
p_ni: 0.001648046
p_wrong: 0.066445545
Score: 0.187
Data Source: BioPlex,STRINGDB
TUBB3
Novelty: 0.00195963
p_int: 0.814313587
p_ni: 0.185686413
Score: 0.178
Data Source: BioPlex,STRINGDB
WAPL
Novelty: 0.01598061
p_int: 0.809749926
p_ni: 0.190249863
p_wrong: 2.11e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
DYM
Novelty: 0.02348265
p_int: 0.803572329
p_ni: 0.196403425
p_wrong: 0.000024246
Score: 0.165
Data Source: BioPlex,STRINGDB
RAB5IF
Novelty: 0.66468447
p_int: 0.773164281
p_ni: 0.000037051
p_wrong: 0.226798668
Score: 0.223
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (19)
Reactome (13)
KEGG (1)
WikiPathways (5)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Bile acid and bile salt metabolism | ||||
Reactome | Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Reactome | Metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Bile acid and bile salt metabolism | ||||
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR) | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (3)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Disease Associations ()
GWAS Traits (34)
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bilirubin measurement | 6 | 14 | 24 | 99.9 | |||||
blood metabolite measurement | 2 | 4 | 14 | 98.8 | |||||
sex hormone-binding globulin measurement | 7 | 3 | 7 | 97.8 | |||||
serum metabolite measurement | 1 | 3 | 10 | 97.2 | |||||
testosterone measurement | 4 | 2 | 4 | 91.9 | |||||
Items per page:
1 – 5 of 34
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bilirubin measurement | 24 | 99.9 | |||||
blood metabolite measurement | 14 | 98.8 | |||||
sex hormone-binding globulin measurement | 7 | 97.8 | |||||
serum metabolite measurement | 10 | 97.2 | |||||
testosterone measurement | 4 | 91.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | solute carrier organic anion transporter family member 1B1 | VGNC:8551 | 465331 | |||||
Macaque | solute carrier organic anion transporter family member 1B1 | 705308 | ||||||
Dog | solute carrier organic anion transporter family member 1B3 | 403519 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | solute carrier organic anion transporter family member 1B1 | |||||
Macaque | solute carrier organic anion transporter family member 1B1 | |||||
Dog | solute carrier organic anion transporter family member 1B3 | |||||
Publication Statistics
PubMed Score 845.62
PubMed score by year
PubTator Score 580.98
PubTator score by year
Related Publications
Text Mined References (299)
GeneRif Annotations (230)
Items per page:
0 of 0
PMID | Year | Title |
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