Tchem SLCO1B1 Solute carrier organic anion transporter family member 1B1

Protein Summary

Description

Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9Y6L6
• B2R7G2
• Q29R64
• Q9NQ37
• Q9UBF3
• Q9UH89

Gene Name

• SLCO1B1

Ensembl ID

• ENST00000256958
• ENSP00000256958
• ENSG00000134538

Symbol

• LST1
• OATP1B1
• OATP2
• OATPC
• SLC21A6
• LST1
• HBLRR
• LST-1
• OATP2
• OATPC
• OATP-C
• OATP1B1
• SLC21A6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
biological term	0.9
chemical	0.86
disease	0.8
phenotype	0.62

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 1b1

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 1b1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 1b1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 938.03   (req: < 5)

Gene RIFs: 314   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 938.03   (req: >= 5)

Gene RIFs: 314   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 11