Tchem SLCO1B1 Solute carrier organic anion transporter family member 1B1

Protein Classes

PANTHER Classes

Protein / Transporter / Solute Carrier Organic Anion Transporter Family Member 1B1

Protein / ... / Protease Inhibitor / Solute Carrier Organic Anion Transporter Family Member 1B1

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slco Family Of Organic Anion Transporting Polypeptides / Solute Carrier Organic Anion Transporter Family Member 1B1

Protein Summary

Description

Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q9Y6L6
• B2R7G2
• Q29R64
• Q9NQ37
• Q9UBF3
• Q9UH89

Gene Name

• SLCO1B1

Ensembl ID

• ENST00000256958
• ENSP00000256958
• ENSG00000134538

Symbol

• LST1
• OATP1B1
• OATP2
• OATPC
• SLC21A6
• LST1
• HBLRR
• LST-1
• OATP2
• OATPC
• OATP-C
• OATP1B1
• SLC21A6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
drug	1
biological term	0.9
chemical	0.86
disease	0.8
phenotype	0.62

Related Tools

RESOLUTE

RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.49   (req: < 5)

Gene RIFs: 230   (req: <= 3)

Antibodies: 156   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.49   (req: >= 5)

Gene RIFs: 230   (req: > 3)

Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2

Approved Drugs (2)

Explore Approved Drugs

1 – 2 of 2

ciclosporin

SLCO1B1Tchem Transporter

INHIBITOR Ki : 7.29

estrone sulphate

SLCO1B1Tchem Transporter

IC50 : 7.21999979

Active Ligands (4)

Explore Active Ligands

1 – 4 of 4

CHEMBL386389

SLCO1B1Tchem Transporter

IC50 : 6.07

CHEMBL3704745

SLCO1B1Tchem Transporter

IC50 : 6.35

rifampicin

SLCO1B1Tchem Transporter

Ki : 5.96000004

rifamycin SV

SLCO1B1Tchem Transporter

Ki : 5.69999981

GWAS Traits (35)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 35

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	7	3	7		99.7
testosterone measurement	EFO_0004908	4	2	4		98.5
blood metabolite measurement	EFO_0005664	2	4	14		95.7
response to methotrexate	GO_0031427	1	1	0	12	94.8
vitamin D measurement	EFO_0004631	3	2	3		94.3

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 35

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	7		99.7
testosterone measurement	EFO_0004908	4		98.5
blood metabolite measurement	EFO_0005664	14		95.7
response to methotrexate	GO_0031427	0	12	94.8
vitamin D measurement	EFO_0004631	3		94.3

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Orthologs (3)

1 – 3 of 3

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 1B1	VGNC:8551	465331
Macaque	solute carrier organic anion transporter family member 1B1		705308
Dog	solute carrier organic anion transporter family member 1B3		403519

Species	Name	OMA	EggNOG	Inparanoid
Chimp	solute carrier organic anion transporter family member 1B1
Macaque	solute carrier organic anion transporter family member 1B1
Dog	solute carrier organic anion transporter family member 1B3

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-Q9Y6L6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (19)

Reactome (13)

KEGG (1)

WikiPathways (5)

Bile acid and bile salt metabolism (R-HSA-194068)

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Find Similar Targets

Items per page:

5

1 – 5 of 13

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Reactome	Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	2 targets	R-HSA-5619110
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Reactome	Metabolism	2112 targets	R-HSA-1430728

Name	Explore in Pharos	Explore in Source
Bile acid and bile salt metabolism	43 targets	R-HSA-194068
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)	2 targets	R-HSA-5619110
Disease	1105 targets	R-HSA-1643685
Disorders of transmembrane transporters	178 targets	R-HSA-5619115
Metabolism	2112 targets	R-HSA-1430728

Gene Ontology Terms (10)

Functions (3)

Components (4)

Processes (3)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
bile acid transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
sodium-independent organic anion transmembrane transporter activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
thyroid hormone transmembrane transporter activity	Traceable Author Statement (TAS)	Reactome

Protein-Protein Interactions (93)

Explore Interacting Targets

1 – 10 of 93

• See Interactions on String-DB

USO1

Tbio

Novelty: 0.02066669

p_int: 0.999995224

p_ni: 0.000004776

Score: 0.169

Data Source: BioPlex,STRINGDB

VAMP3

Tbio

Novelty: 0.00694332

p_int: 0.947607911

p_ni: 0.052391858

p_wrong: 2.31e-7

Data Source: BioPlex

MZT2B

Tdark

Novelty: 0.69469786

p_int: 0.937981882

p_ni: 0.037408301

p_wrong: 0.024609817

Score: 0.183

Data Source: BioPlex,STRINGDB

SYNGR2

Tbio

Novelty: 0.1089664

p_int: 0.932512915

p_ni: 0.06746861

p_wrong: 0.000018475

Score: 0.181

Data Source: BioPlex,STRINGDB

ORMDL2

Tdark

Novelty: 0.37598406

p_int: 0.931906408

p_ni: 0.001648046

p_wrong: 0.066445545

Score: 0.187

Data Source: BioPlex,STRINGDB

TUBB3

Tclin

Novelty: 0.00195963

p_int: 0.814313587

p_ni: 0.185686413

Score: 0.178

Data Source: BioPlex,STRINGDB

WAPL

Tbio

Novelty: 0.01598061

p_int: 0.809749926

p_ni: 0.190249863

p_wrong: 2.11e-7

Score: 0.19

Data Source: BioPlex,STRINGDB

DYM

Tbio

Novelty: 0.02348265

p_int: 0.803572329

p_ni: 0.196403425

p_wrong: 0.000024246

Score: 0.165

Data Source: BioPlex,STRINGDB

RAB5IF

Tdark

Novelty: 0.66468447

p_int: 0.773164281

p_ni: 0.000037051

p_wrong: 0.226798668

Score: 0.223

Data Source: BioPlex,STRINGDB

ALB

Tchem

Novelty: 0.00000616

Score: 0.964

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score  816.49

PubMed score by year

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PubTator Score  580.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Cell membrane
Complete proteome
Disulfide bond
Glycoprotein
Ion transport
Membrane
Phosphoprotein
Polymorphism
Reference proteome
Transmembrane

GWAS Trait Find Similar Targets

acute coronary syndrome
AR-C124910XX measurement
bilirubin measurement
blood metabolite measurement
chronic kidney disease
estrogen-receptor positive breast cancer
estrone conjugate measurement
estrone measurement
heel bone mineral density
Ischemic stroke

MGI Phenotype Find Similar Targets

homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging