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Tchem
SLCO1B1
Solute carrier organic anion transporter family member 1B1

Protein Summary
Description
Mediates the Na(+)-independent uptake of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, 17-beta-glucuronosyl estradiol, estrone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, leukotriene E4, thyroxine and triiodothyronine. Involved in the clearance of bile acids and organic anions from the liver. This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256958
  • ENSP00000256958
  • ENSG00000134538

Symbol
  • LST1
  • OATP1B1
  • OATP2
  • OATPC
  • SLC21A6
  • LST1
  • HBLRR
  • LST-1
  • OATP2
  • OATPC
  • OATP-C
  • OATP1B1
  • SLC21A6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
biological term
0.9
chemical
0.86
disease
0.8
phenotype
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.49   (req: < 5)
Gene RIFs: 230   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 816.49   (req: >= 5)
Gene RIFs: 230   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (35)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
3
7
99.7
testosterone measurement
4
2
4
98.5
blood metabolite measurement
2
4
14
95.7
response to methotrexate
1
1
0
12
94.8
vitamin D measurement
3
2
3
94.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
7
99.7
testosterone measurement
4
98.5
blood metabolite measurement
14
95.7
response to methotrexate
0
12
94.8
vitamin D measurement
3
94.3
Pathways (19)
Bile acid and bile salt metabolism (R-HSA-194068)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Bile acid and bile salt metabolism
Reactome
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Bile acid and bile salt metabolism
Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)
Disease
Disorders of transmembrane transporters
Metabolism
Protein-Protein Interactions (93)
1 – 10 of 93
USO1
Tbio
Novelty: 0.02066669
p_int: 0.999995224
p_ni: 0.000004776
Score: 0.169
Data Source: BioPlex,STRINGDB
VAMP3
Tbio
Novelty: 0.00694332
p_int: 0.947607911
p_ni: 0.052391858
p_wrong: 2.31e-7
Data Source: BioPlex
MZT2B
Tdark
Novelty: 0.69469786
p_int: 0.937981882
p_ni: 0.037408301
p_wrong: 0.024609817
Score: 0.183
Data Source: BioPlex,STRINGDB
SYNGR2
Tbio
Novelty: 0.1089664
p_int: 0.932512915
p_ni: 0.06746861
p_wrong: 0.000018475
Score: 0.181
Data Source: BioPlex,STRINGDB
ORMDL2
Tdark
Novelty: 0.37598406
p_int: 0.931906408
p_ni: 0.001648046
p_wrong: 0.066445545
Score: 0.187
Data Source: BioPlex,STRINGDB
TUBB3
Tclin
Novelty: 0.00195963
p_int: 0.814313587
p_ni: 0.185686413
Score: 0.178
Data Source: BioPlex,STRINGDB
WAPL
Tbio
Novelty: 0.01598061
p_int: 0.809749926
p_ni: 0.190249863
p_wrong: 2.11e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
DYM
Tbio
Novelty: 0.02348265
p_int: 0.803572329
p_ni: 0.196403425
p_wrong: 0.000024246
Score: 0.165
Data Source: BioPlex,STRINGDB
RAB5IF
Tdark
Novelty: 0.66468447
p_int: 0.773164281
p_ni: 0.000037051
p_wrong: 0.226798668
Score: 0.223
Data Source: BioPlex,STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.964
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  816.49

PubMed score by year
PubTator Score  580.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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