Tbio IKBKG NF-kappa-B essential modulator

Protein Summary

Description

Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9Y6K9
• Q7LBY6
• Q7Z7F1
• NEMO

Gene Name

• IKBKG

Ensembl ID

• ENST00000594239
• ENSP00000471166
• ENSG00000269335
• ENST00000611071
• ENSP00000479662
• ENST00000611176
• ENSP00000478616
• ENST00000618670
• ENSP00000483825

Symbol

• FIP3
• NEMO
• IP
• IP1
• IP2
• FIP3
• IKKG
• IPD2
• NEMO
• FIP-3
• Fip3p
• IMD33
• AMCBX1
• EDAID1
• IKKAP1
• ZC2HC9
• IKK-gamma

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
hub protein	1
kinase perturbation	1
disease perturbation	0.99
pathway	0.98

Protein Classes

DTO Classes

Protein / Kinase / Protein Kinase / Nf-kappa-b Essential Modulator

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429.51   (req: < 5)

Gene RIFs: 208   (req: <= 3)

Antibodies: 1102   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2429.51   (req: >= 5)

Gene RIFs: 208   (req: > 3)

Antibodies: 1102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0