Tclin DNMT3A DNA (cytosine-5)-methyltransferase 3A

Protein Summary

Description

Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]

Uniprot Accession IDs

• Q9Y6K1
• E9PEB8
• Q86TE8
• Q86XF5
• Q8IZV0
• Q8WXU9
• Dnmt3a

Gene Name

• DNMT3A

Ensembl ID

• ENST00000264709
• ENSP00000264709
• ENSG00000119772
• ENST00000321117
• ENSP00000324375
• ENST00000380746
• ENSP00000370122
• ENST00000406659
• ENSP00000384852

Symbol

• TBRS
• DNMT3A2
• M.HsaIIIA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	0.95
transcription factor	0.93
transcription factor binding site profile	0.92
PubMedID	0.9
transcription factor perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.34   (req: < 5)

Gene RIFs: 492   (req: <= 3)

Antibodies: 914   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1423.34   (req: >= 5)

Gene RIFs: 492   (req: > 3)

Antibodies: 914   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2