DNMT3A
DNA (cytosine-5)-methyltransferase 3A
Protein Summary
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, ...more
- ENST00000264709
- ENSP00000264709
- ENSG00000119772
- ENST00000321117
- ENSP00000324375
- ENST00000380746
- ENSP00000370122
- ENST00000406659
- ENSP00000384852
- TBRS
- DNMT3A2
- M.HsaIIIA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.95 | ||
transcription factor | 0.93 | ||
transcription factor binding site profile | 0.92 | ||
PubMedID | 0.9 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1222.57 (req: < 5)
Gene RIFs: 319 (req: <= 3)
Antibodies: 914 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1222.57 (req: >= 5)
Gene RIFs: 319 (req: > 3)
Antibodies: 914 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 30
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 3
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (2)
Active Ligands (3)
Protein-Protein Interactions (272)
TCL1A
Novelty: 0.00606987
p_int: 0.999999991
p_ni: 8e-9
Score: 0.531
Data Source: BioPlex,STRINGDB
DNMT3B
Family: Epigenetic
Novelty: 0.00118766
p_int: 0.99999999
p_ni: 6e-9
p_wrong: 3e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (32)
Reactome (12)
KEGG (3)
PathwayCommons (1)
WikiPathways (16)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | DNA methylation | ||||
Reactome | Epigenetic regulation of gene expression | ||||
Reactome | Gene expression (Transcription) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
DNA methylation | ||||
Epigenetic regulation of gene expression | ||||
Gene expression (Transcription) | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (9)
Components (8)
Processes (21)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (28)
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 6 | 19 | 26 | 96.2 | |||||
body height | 3 | 2 | 3 | 91.5 | |||||
neutrophil percentage of leukocytes | 2 | 3 | 3 | 91.2 | |||||
BMI-adjusted hip circumference | 2 | 9 | 10 | 91.2 | |||||
BMI-adjusted waist-hip ratio | 4 | 8 | 9 | 90.4 | |||||
Items per page:
1 – 5 of 28
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist circumference | 26 | 96.2 | |||||
body height | 3 | 91.5 | |||||
neutrophil percentage of leukocytes | 3 | 91.2 | |||||
BMI-adjusted hip circumference | 10 | 91.2 | |||||
BMI-adjusted waist-hip ratio | 9 | 90.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA methyltransferase 3 alpha | VGNC:219 | 739139 | |||||
Macaque | DNA methyltransferase 3 alpha | 694822 | ||||||
Mouse | MGI:1261827 | 13435 | ||||||
Rat | RGD:1303336 | 444984 | ||||||
Dog | DNA methyltransferase 3 alpha | VGNC:40036 | 482996 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA methyltransferase 3 alpha | |||||
Macaque | DNA methyltransferase 3 alpha | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA methyltransferase 3 alpha | |||||
Publication Statistics
PubMed Score 1222.57
PubMed score by year
PubTator Score 670.16
PubTator score by year
Related Publications
Text Mined References (351)
GeneRif Annotations (319)
Items per page:
0 of 0
PMID | Year | Title |
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