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Tclin
DNMT3A
DNA (cytosine-5)-methyltransferase 3A

Protein Summary
Description
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZBTB18. Recruited to trimethylated 'Lys-36' of histone H3 (H3K36me3) sites. Can actively repress transcription through the recruitment of HDAC activity. CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264709
  • ENSP00000264709
  • ENSG00000119772
  • ENST00000321117
  • ENSP00000324375
  • ENST00000380746
  • ENSP00000370122
  • ENST00000406659
  • ENSP00000384852

Symbol
  • TBRS
  • DNMT3A2
  • M.HsaIIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.95
transcription factor
0.93
transcription factor binding site profile
0.92
PubMedID
0.9
transcription factor perturbation
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157   (req: < 5)
Gene RIFs: 319   (req: <= 3)
Antibodies: 914   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1157   (req: >= 5)
Gene RIFs: 319   (req: > 3)
Antibodies: 914   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 30
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Active Ligands (1)
1 – 1 of 1
CHEMBL2336409
chemical structure image
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
2
3
90.4
BMI-adjusted waist-hip ratio
2
2
2
89.3
heel bone mineral density
2
1
2
88.2
BMI-adjusted waist circumference
4
2
8
66.3
hematocrit
2
2
2
66.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
90.4
BMI-adjusted waist-hip ratio
2
89.3
heel bone mineral density
2
88.2
BMI-adjusted waist circumference
8
66.3
hematocrit
2
66.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 3 alpha
VGNC:219
739139
Macaque
DNA methyltransferase 3 alpha
694822
Mouse
MGI:1261827
13435
Rat
RGD:1303336
444984
Dog
DNA methyltransferase 3 alpha
VGNC:40036
482996
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA methyltransferase 3 alpha
Macaque
DNA methyltransferase 3 alpha
Mouse
Rat
Dog
DNA methyltransferase 3 alpha
Protein Structure (13 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y6K1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 13
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
DNA methylation
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
DNA methylation
Epigenetic regulation of gene expression
Gene expression (Transcription)
Gene Ontology Terms (38)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (272)
1 – 10 of 272
TCL1A
Tbio
Novelty: 0.00606987
p_int: 0.999999991
p_ni: 8e-9
Score: 0.531
Data Source: BioPlex,STRINGDB
DNMT3B
Tchem
Family: Epigenetic
Novelty: 0.00118766
p_int: 0.99999999
p_ni: 6e-9
p_wrong: 3e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
DNMT1
Tclin
Family: Enzyme
Novelty: 0.00042336
Score: 0.996
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.991
Data Source: Reactome,STRINGDB
DNMT3L
Tbio
Family: Enzyme
Novelty: 0.0070698
Score: 0.99
Data Source: Reactome,STRINGDB
MYC
Tbio
Family: TF
Novelty: 0.00005734
Score: 0.981
Data Source: STRINGDB
PRMT5
Tchem
Family: Epigenetic
Novelty: 0.00395474
Score: 0.981
Data Source: STRINGDB
CBX4
Tchem
Family: Epigenetic
Novelty: 0.02681197
Score: 0.972
Data Source: STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
Score: 0.966
Data Source: Reactome,STRINGDB
HIST2H2AC
Tbio
Novelty: 0.00065524
Score: 0.959
Data Source: STRINGDB
Publication Statistics
PubMed Score  1157.00

PubMed score by year
PubTator Score  670.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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