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Tbio
CABIN1
Calcineurin-binding protein cabin-1

Protein Summary
Description
May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals. Acts as a negative regulator of p53/TP53 by keeping p53 in an inactive state on chromatin at promoters of a subset of it's target genes. Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263119
  • ENSP00000263119
  • ENSG00000099991
  • ENST00000398319
  • ENSP00000381364
  • ENST00000405822
  • ENSP00000384694

Symbol
  • KIAA0330
  • CAIN
  • PPP3IN
  • KB-318B8.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.89
transcription factor binding site profile
0.76
histone modification site profile
0.75
tissue sample
0.72
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.53   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 81   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.53   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 81   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (132)
ASF1B
Tbio
Novelty:  0.05716701
p_int:  0.99999999
p_ni:  9e-9
Score:  0.574
Data Source:  BioPlex,STRINGDB
ASF1A
Tchem
Novelty:  0.02544466
p_int:  0.999999952
p_ni:  4.8e-8
Score:  0.982
Data Source:  BioPlex,Reactome,STRINGDB
CDX1
Tbio
Family:  TF
Novelty:  0.00815821
p_int:  0.999997233
p_ni:  0.000002767
Data Source:  BioPlex
HMGA1
Tbio
Family:  TF
Novelty:  0.00185669
p_int:  0.999978195
p_ni:  0.000021805
Score:  0.903
Data Source:  BioPlex,Reactome,STRINGDB
EAF1
Tbio
Novelty:  0.81120425
p_int:  0.999970473
p_ni:  0.000029527
Score:  0.199
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.999915346
p_ni:  0.000084654
Data Source:  BioPlex
TFAP4
Tbio
Family:  TF
Novelty:  0.03155887
p_int:  0.999537686
p_ni:  0.000462314
Score:  0.175
Data Source:  BioPlex,STRINGDB
MEF2B
Tbio
Family:  TF
Novelty:  0.03094093
p_int:  0.991406975
p_ni:  0.008593017
p_wrong:  9e-9
Score:  0.944
Data Source:  BioPlex,STRINGDB
TLK2
Tchem
Family:  Kinase
Novelty:  0.07082609
p_int:  0.962760265
p_ni:  0.01010522
p_wrong:  0.027134515
Score:  0.806
Data Source:  BioPlex,STRINGDB
MEF2D
Tbio
Family:  TF
Novelty:  0.00732653
Score:  0.99
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
DNA Damage/Telomere Stress Induced Senescence
Reactome
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
DNA Damage/Telomere Stress Induced Senescence
Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
4
13
12
3.7
99.4
monocyte count
2
2
2
93.4
lymphocyte count
2
2
2
83.9
eosinophil count
3
1
3
81.1
myeloid white cell count
1
1
1
75.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
12
3.7
99.4
monocyte count
2
93.4
lymphocyte count
2
83.9
eosinophil count
3
81.1
myeloid white cell count
1
75.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
calcineurin binding protein 1
VGNC:5235
458709
Mouse
MGI:1298375
104248
Rat
RGD:620263
94165
Dog
calcineurin binding protein 1
VGNC:38621
486403
Horse
calcineurin binding protein 1
VGNC:15972
100053375
Species
Name
OMA
EggNOG
Inparanoid
Chimp
calcineurin binding protein 1
Mouse
Rat
Dog
calcineurin binding protein 1
Horse
calcineurin binding protein 1
Publication Statistics
PubMed Score 43.53
PubMed score by year
PubTator Score 1583.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title