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Tbio
WSB1
WD repeat and SOCS box-containing protein 1

Protein Summary
Description
Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes type II iodothyronine deiodinase/DIO2. Confers constitutive instability to HIPK2 through proteasomal degradation. This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262394
  • ENSP00000262394
  • ENSG00000109046
  • ENST00000348811
  • ENSP00000327055

Symbol
  • SWIP1
  • SWIP1
  • WSB-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
0.94
transcription factor binding site profile
0.91
protein domain
0.85
virus perturbation
0.83
transcription factor perturbation
0.74


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.42   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (332)
1 – 10 of 332
CUL5
Tbio
Novelty: 0.01021591
p_int: 1
Score: 0.953
Data Source: BioPlex,STRINGDB
RNF7
Tbio
Novelty: 0.03533891
p_int: 0.99999999
p_ni: 2e-9
p_wrong: 8e-9
Score: 0.914
Data Source: BioPlex,STRINGDB
SIAH2
Tbio
Family: Enzyme
Novelty: 0.01729844
Score: 0.959
Data Source: STRINGDB
SIAH1
Tbio
Family: Enzyme
Novelty: 0.01035087
Score: 0.956
Data Source: STRINGDB
CISH
Tbio
Novelty: 0.00075253
Score: 0.952
Data Source: STRINGDB
ELOB
Tbio
Novelty: 0.02073979
Score: 0.952
Data Source: STRINGDB
ELOC
Tbio
Novelty: 0.0146568
Score: 0.95
Data Source: STRINGDB
LRRC41
Tdark
Novelty: 0.40145985
Score: 0.949
Data Source: STRINGDB
FBXW8
Tbio
Novelty: 0.08804388
Score: 0.944
Data Source: STRINGDB
SPSB4
Tdark
Novelty: 0.18018018
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  17.42

PubMed score by year
PubTator Score  11.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer