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Tbio
USP3
Ubiquitin carboxyl-terminal hydrolase 3

Protein Summary
Description
Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380324
  • ENSP00000369681
  • ENSG00000140455
  • ENST00000540797
  • ENSP00000445828

Symbol
  • UBP
  • SIH003
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
molecular function
0.95
transcription factor perturbation
0.94
kinase perturbation
0.91
transcription factor
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.02   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.02   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0